KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis
KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis
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KPNA2 是上皮性卵巢癌的潜在诊断血清生物标志物，与不良预后相关
DOI：
10.1177/1010428317706289
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发表时间：
2017-06-27
期刊：
影响因子：
--
通讯作者：
Zheng, Min
中科院分区：
文献类型：
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作者：
Huang, Long;Zhou, Yun;Zheng, Min
本研究的目的是确定是否血清细胞核转运蛋白α 2水平可以作为诊断卵巢上皮性癌的生物标志物。采用酶联免疫吸附法检测162例卵巢上皮性癌患者和48例健康对照者血清中Karyopherin α 2蛋白的表达。卵巢上皮性癌患者血清KARO α 2水平显著高于健康对照组（P < 0.001）。当以2.52 µg/mL的血清核粒细胞运载蛋白α 2水平作为临界值时，该检测方法诊断上皮性卵巢癌的灵敏度和特异性分别为71.4%和81.2%。高血清核转运蛋白α 2水平（>485 µg/mL）与国际妇产科联合会分期（p < 0.0001）、淋巴结转移（p = 0.045）、总生存期（p = 0.001）和无病进展（p = 0.006）相关。血清核转运蛋白α 2是一种潜在的上皮性卵巢癌诊断生物标志物。
This study aimed to determine whether serum karyopherin alpha 2 levels can be used as a diagnostic biomarker for epithelial ovarian carcinoma. Karyopherin alpha 2 protein was detected by enzyme-linked immunosorbent assay in serum samples from 162 epithelial ovarian carcinoma patients and 48 healthy controls. Serum karyopherin alpha 2 levels in epithelial ovarian carcinoma patients were significantly higher than in healthy controls (p < 0.001). When a karyopherin alpha 2 serum level of 2.52 µg/mL was used as a cut-off, the sensitivity and specificity of the assay for diagnosing epithelial ovarian carcinoma were 71.4% and 81.2%, respectively. High serum karyopherin alpha 2 levels (>485 µg/mL) correlated with International Federation of Gynecology and Obstetrics stage (p < 0.0001), lymphatic metastasis (p = 0.045), overall survival (p = 0.001), and disease-free progression (p = 0.006). Serum karyopherin alpha 2 represents a potential diagnostic biomarker for epithelial ovarian carcinoma.