Opinion - CpG island methylator phenotype in cancer
Opinion - CpG island methylator phenotype in cancer
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DOI：
10.1038/nrc1507
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发表时间：
2004-12-01
影响因子：
78.5
通讯作者：
Issa, JP
中科院分区：
文献类型：
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作者：
Issa, JP
现在，富含CpG的启动子中的DNA高甲基化被认为是人类肿瘤的共同特征。但是，高甲基化的病理生理（为什么，何时，哪里）仍然晦涩。可以根据其甲基化程度对癌症进行分类，而那些具有高度甲基化（CpG岛甲基表型或CIMP）的癌症代表临床和病因上不同的群体，其特征在于“表观遗传不稳定”。此外，与CIMP相关的癌症似乎具有独特的流行病学，独特的组织学，独特的前体病变和不同的分子特征。
DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of human neoplasia. However, the pathophysiology of hypermethylation (why, when, where) remains obscure. Cancers can be classified according to their degree of methylation, and those cancers with high degrees of methylation (the CpG island methylator phenotype, or CIMP) represent a clinically and aetiologically distinct group that is characterized by 'epigenetic instability'. Furthermore, CIMP-associated cancers seem to have a distinct epidemiology, a distinct histology, distinct precursor lesions and distinct molecular features.