Association of neural and physiological responses during voluntary emotion suppression
Association of neural and physiological responses during voluntary emotion suppression
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DOI：
10.1016/j.neuroimage.2005.08.047
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发表时间：
2006-02-01
期刊：
影响因子：
5.7
通讯作者：
Yamada, J
中科院分区：
文献类型：
--
作者：
Ohira, H;Nomura, M;Yamada, J
最近的神经影像学研究表明，在自愿情绪调节过程中，前额叶的几个区域在抑制边缘系统区域的激活中起着关键作用。本研究的目的是确认以前的研究结果，并通过确定与调节自愿情绪抑制过程中的外周生理反应相关的额叶神经回路来扩展它们。10名健康女性受试者提出了情感积极，中性和消极的图片在每一个出席和抑制任务。区域脑血流量的变化进行了测量，使用O-15-水正电子发射断层扫描，自主神经（心率：HR，皮肤电导反应：SCR）和内分泌（促肾上腺皮质激素：ACTH）的指标进行了测量在这两个任务。左杏仁核和右前颞极在主治任务期间被激活，而激活观察到在左侧前额叶皮层（LPFC），包括相邻的内侧前额叶皮层（MPFC），内侧眶额皮层（MOFC）在抑制任务。在主治任务中，杏仁核和MOFC的激活与SCR和ACTH反应的幅度呈正相关。情绪抑制引起SCR的增强和强度的影响呈正相关的激活MOFC。这些结果表明，MOFC在自上而下调节伴随情绪体验的外周生理反应中起着关键作用。(c)2005年爱思唯尔公司All rights reserved.
Recent neuromiaging studies have shown that several prefrontal regions play critical roles in inhibiting activation of limbic regions during voluntary emotion regulation. The present study aimed to confirm prior findings and to extend them by identifying the frontal neural circuitry associated with regulation of peripheral physiological responses during voluntary emotion suppression. Ten healthy female subjects were presented with affectively positive, neutral, and negative pictures in each of an Attending and Suppression task. Regional cerebral blood-flow changes were measured using O-15-water positron emission tomography, and autonomic (heart rate: HR, skin conductance response: SCR) and endocrine (adrenocorticotropic hormone: ACTH) indices were measured during both tasks. The left amygdala and the right anterior temporal pole were activated during the Attending task, whereas activation was observed in the left lateral prefrontal cortex (LPFC), including the adjacent medial prefrontal cortex (MPFC), and medial orbitofrontal cortex (MOFC) during the Suppression task. In the Attending task, activation in the amygdala and MOFC positively correlated with magnitudes of the SCR and ACTH responses. Emotion suppression elicited enhancement of SCR and the strength of the effect positively correlated with activation in the MOFC. These results suggest that the MOFC plays a pivotal role in top-down regulation of peripheral physiological responses accompanying emotional experiences. (c) 2005 Elsevier Inc. All rights reserved.