Assessment of Rodents as Animal Models for Reston Ebolavirus
Assessment of Rodents as Animal Models for Reston Ebolavirus
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DOI：
10.1093/infdis/jir330
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发表时间：
2011-11-01
影响因子：
6.4
通讯作者：
Feldmann, Heinz
中科院分区：
文献类型：
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作者：
de Wit, Emmie;Munster, Vincent J.;Feldmann, Heinz
莱斯顿埃博拉病毒（REBOV）在菲律宾家猪中的出现引起了人们对REBOV致病性的新兴趣。在此，研究了不同啮齿动物物种作为REBOV的动物疾病模型的用途。BALB/c和STAT 1（-/-）小鼠、Hartley豚鼠和叙利亚仓鼠腹腔内接种REBOV毒株Pennsylvania或Reston 08-A。尽管病毒复制发生在豚鼠、仓鼠和STAT 1（-/-）小鼠中，但仅在STAT 1（-/-）小鼠中观察到疾病进展。此外，在该模型中，REBOV Pennsylvania比REBOV Reston 08-A更具致病性。因此，STAT 1（-/-）小鼠可用于REBOV致病性和干预策略的研究。
The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-/-) mice may be used for research of REBOV pathogenicity and intervention strategies.