Medical termination of pregnancy.
Medical termination of pregnancy.
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医疗终止妊娠。
DOI：
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发表时间：
2000
影响因子：
158.5
通讯作者：
I. R. M. S. Pitz
中科院分区：
文献类型：
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作者：
S. O. C. Hristin;P. Hilippe;B. Ouchard;I. R. M. S. Pitz
本次审查的重点是在医疗终止妊娠的早期怀孕的第一个三个月，当大多数堕胎进行的进展。这些药物通过抑制孕酮的合成、诱导子宫肌层收缩、拮抗孕酮的作用或抑制滋养层发育来终止妊娠。用于药物流产的药物有依泊斯坦、阿替兰丁（包括米索前列醇和geprost）、氨甲蝶呤和米索前列醇联合用药、他莫昔芬-米索前列醇方案、米非司酮和前列腺素以及抗孕酮和阿替兰丁。这些药物的疗效，副作用和禁忌症的药物终止妊娠进行了讨论。一般来说，与手术流产相比，药物流产与长期出血、恶心、呕吐和疼痛的发生率较高有关。然而，药物终止妊娠在早孕妇女中的有效率很高。此外，药物流产是安全的，妇女可以接受，它不需要麻醉。最后，选择药物流产的妇女，如果发生大出血，需要输血，必须到提供吸引刮宫的中心就诊。
This review focuses on advances in the medical termination of pregnancy during the early period of the first trimester, when most abortions are performed. The drugs are used to terminate pregnancy act by inhibiting the synthesis of progesterone, inducing myometrial contractions, antagonizing the action of progesterone, or inhibiting trophoblast development. Among the drugs used in medical abortion are epostane, prostaglandins (including misoprostol and gameprost), combined methotrexate and misoprostol, tamoxifen-misoprostol regimen, mifepristone and prostaglandin, and antiprogestin and prostaglandins. The efficacy, side effects, and contraindications of these drugs in the medical termination of pregnancy are discussed. In general, medical abortion is associated with higher rates of prolonged bleeding, nausea, vomiting, and pain as compared to surgical abortion. However, medical termination of pregnancy has a high rate of efficacy in women with early pregnancies. In addition, medical abortion is safe and acceptable to women, and it does not require anesthesia. Lastly, women who choose medical abortion must have access to a center where suction curettage is available, should heavy bleeding occur and blood transfusion is required.