Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers
Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers
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DOI：
10.1046/j.1523-1747.2000.00096.x
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发表时间：
2000-11-01
影响因子：
6.5
通讯作者：
Wahn, U
中科院分区：
文献类型：
--
作者：
Beyer, K;Nickel, R;Wahn, U
特应性皮炎是一种慢性炎症性皮肤病，影响10-20%的人口。特应性、哮喘、过敏性鼻炎和血清总IgE水平与几个不同染色体区域的联系已被广泛描述，但对特应性皮炎的遗传控制知之甚少。我们检测了特应性皮炎与5个染色体区域之间的关联和连锁：5 q31 -33、6p21.3、12 q15 -24.1、13 q12 -31和14q11.2/14q32.1-32.3。在两个高加索人群中进行标记物分析：（i）来自德国出生队列研究（MAS'90）的192名患有特应性皮炎的无关德国儿童和59名非特应性儿童，在192名患有特应性皮炎的儿童中的77名中测试了父母DNA;（ii）40个瑞典家庭，至少有一名家庭成员患有特应性皮炎，选自国际儿童哮喘和过敏研究。在染色体13 q12 -14和5 q31 -33上的标记观察到特应性皮炎的连锁和等位基因关联的证据。
Atopic dermatitis is a chronic inflammatory skin disease that affects 10-20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic control of atopic dermatitis. We tested for the association and linkage between atopic dermatitis and five chromosomal regions: 5q31-33, 6p21.3, 12q15-24.1, 13q12-31, and 14q11.2/14q32.1-32.3. Marker analysis was performed in two Caucasian populations: (i) 192 unrelated German children with atopic dermatitis and 59 non-atopic children from a German birth cohort study (MAS'90), parental DNA was tested in 77 of 192 children with atopic dermatitis; (ii) 40 Swedish families with at least one family member with atopic dermatitis selected from the International Study of Asthma and Allergy in Children. Evidence for linkage and allelic association for atopic dermatitis was observed for markers on chromosome 13q12-14 and 5q31-33.