Overcompensation stimulation: A mechanism for hormetic effects
Overcompensation stimulation: A mechanism for hormetic effects
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DOI：
10.1080/20014091111749
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发表时间：
2001-01-01
影响因子：
5.9
通讯作者：
Calabrese, EJ
中科院分区：
文献类型：
--
作者：
Calabrese, EJ
兴奋性反应是由直接刺激还是过度补偿刺激引起的，一直是辐射毒理学和化学毒理学中一个未解决且有争议的问题。本文的目的是确定在生物/生物医学文献中的过度补偿刺激的许多例子，并评估其描述性和定量特征。这些发现为以下假设提供了支持：来自广泛的生物模型的激素剂量-反应关系可以在稳态初始破坏后发生。这一发现也表明了时间因素在剂量反应关系评估中的重要作用。
Whether hormetic responses result from a direct or an overcompensation type of stimulatory response has been an unresolved and contentious issue in both radiation and chemical toxicology. The goal of the present article is to identify numerous examples of overcompensation stimulation in the biological/biomedical literature and to evaluate their descriptive and quantitative features. The findings provide support for the hypothesis that hormetic dose-response relationships from a broad array of biological models can occur after an initial disruption in homeostasis. The finding also demonstrates the significant role of temporal factors in the assessment of dose response relationships.