Trace Minerals, Heavy Metals, and Preeclampsia: Findings from the Boston Birth Cohort
Trace Minerals, Heavy Metals, and Preeclampsia: Findings from the Boston Birth Cohort
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DOI：
10.1161/jaha.119.012436
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发表时间：
2019-08-20
影响因子：
5.4
通讯作者：
Mueller, Noel T.
中科院分区：
文献类型：
--
作者：
Liu, Tiange;Zhang, Mingyu;Mueller, Noel T.
背景-先兆子痫是孕产妇和围产期发病率和死亡率的主要原因。在小鼠实验中，锰（Mn）和硒（Se）是保护性的，而镉（Cd）是促进先兆子痫。这些化学元素的流行病学调查结果一直不一致。为了确认在小鼠中的实验结果，我们研究了微量元素（锰和硒）和重金属（镉，铅[Pb]，汞[Hg]）与先兆子痫在出生cohol.Methods和结果，共1274名妇女从波士顿出生队列（自1998年以来注册）的暴露和结果的完整数据。我们测量锰，硒，镉，铅，汞从红细胞内收集的24至72小时后交付。我们从病历中确定了先兆子痫的诊断。我们使用泊松回归和稳健方差模型来估计患病率（PR）和95% CI。共有115名（9.0%）妇女发展为先兆子痫。我们观察到Mn的剂量反应趋势的证据（P趋势
Background-Preeclampsia is a leading contributor to maternal and perinatal morbidity and mortality. In mice experiments, manganese (Mn) and selenium (Se) are protective whereas cadmium (Cd) is promotive for preeclampsia. Epidemiologic findings on these chemical elements have been inconsistent. To confirm experimental findings in mice, we examined associations of trace minerals (Mn and Se) and heavy metals (Cd, lead [Pb], and mercury [Hg]) with preeclampsia in a birth cohort.Methods and Results-A total of 1274 women from the Boston Birth Cohort (enrolled since 1998) had complete data on the exposures and outcome. We measured Mn, Se, Cd, Pb, and Hg from red blood cells collected within 24 to 72 hours after delivery. We ascertained preeclampsia diagnosis from medical records. We used Poisson regression with robust variance models to estimate prevalence ratios (PRs) and 95% CIs. A total of 115 (9.0%) women developed preeclampsia. We observed evidence of a dose-response trend for Mn (P for trend