Dynamics of neural population responses in prefrontal cortex indicate changes of mind on single trials.
Dynamics of neural population responses in prefrontal cortex indicate changes of mind on single trials.
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DOI：
10.1016/j.cub.2014.05.049
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发表时间：
2014-07-07
期刊：
影响因子：
--
通讯作者：
Newsome WT
中科院分区：
文献类型：
--
作者：
Kiani R;Cueva CJ;Reppas JB;Newsome WT
决策是一个复杂的过程，其中不同的信息源被组合成指导行动的决策变量（DV）。神经生理学研究通常通过对顺序记录的单个神经元或小群神经元的大量试验进行统计分析来深入了解决策过程的动态及其神经机制。然而，检测和分析单个试验中的 DV 一直具有挑战性。在这里，我们表明，通过同时记录执行方向辨别任务的猕猴前弓回的数百个单元，我们可以高精度预测猴子的选择，并随着个体试验的决策展开动态解码 DV。这一进展使我们能够研究在最终做出决定之前偶尔发生的想法改变 (CoM)。在个别试验中，解码的 DV 随着时间的推移发生显着变化，并且偶尔会改变其符号，从而识别出潜在的 CoM。通过在刺激呈现后的延迟期内随机停止决策过程来询问系统，确认了已识别 CoM 的有效性。重要的是，候选 CoM 的属性也符合基于先前理论和行为研究的预期：它们更有可能从错误选择变为正确选择；他们更有可能接受弱刺激和中等刺激，而不是强刺激；而且他们更有可能是在审判的早期。我们认为，同时记录大型神经群体可以很好地估计 DV，并解释决策过程中以前无法实现的特殊方面。
Decision-making is a complex process in which different sources of information are combined into a decision variable (DV) that guides action. Neurophysiological studies have typically sought insight into the dynamics of the decision-making process and its neural mechanisms through statistical analysis of large numbers of trials from sequentially recorded single neurons or small groups of neurons. However, detecting and analyzing the DV on individual trials has been challenging. Here we show that by recording simultaneously from hundreds of units in pre-arcuate gyrus of macaque monkeys performing a direction discrimination task, we can predict the monkey’s choices with high accuracy and decode DV dynamically as the decision unfolds on individual trials. This advance enabled us to study changes-of-mind (CoM’s) that occasionally happen before the final commitment to a decision. On individual trials, the decoded DV varied significantly over time and occasionally changed its sign, identifying a potential CoM. Interrogating the system by random stopping of the decision-making process during the delay period after stimulus presentation confirmed the validity of identified CoM’s. Importantly, the properties of the candidate CoM’s also conformed to expectations based on prior theoretical and behavioral studies: they were more likely to go from an incorrect to a correct choice; they were more likely for weak and intermediate stimuli than for strong stimuli; and they were more likely earlier in the trial. We suggest that simultaneous recording of large neural populations provides a good estimate of DV and explains idiosyncratic aspects of the decision-making process that were inaccessible before.
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影响因子：
16.2
作者：
Ding L;Gold JI
通讯作者：
Gold JI
影响因子：
5.5
作者：
Carpenter, R. H. S.;Reddi, B. A. J.;Anderson, A. J.
通讯作者：
Anderson, A. J.
DOI：
10.1523/jneurosci.4075-12.2013
发表时间：
2013-01-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hussar CR;Pasternak T
通讯作者：
Pasternak T
影响因子：
16.2
作者：
Heitz RP;Schall JD
通讯作者：
Schall JD
影响因子：
2.5
作者：
Horwitz, GD;Newsome, WT
通讯作者：
Newsome, WT