Thyrotropin releasing hormone
Thyrotropin releasing hormone
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促甲状腺激素释放激素
DOI：
10.1007/bf00230085
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发表时间：
1982
影响因子：
4.3
通讯作者：
M. Gershengorn
中科院分区：
文献类型：
--
作者：
M. Gershengorn
促甲状腺素释放激素（TRH）可刺激垂体前叶细胞释放促甲状腺素（TSH）和催乳素。大量的研究已经在肿瘤和非肿瘤垂体细胞中进行，以阐明参与这一作用的细胞内事件的顺序。虽然环AMP被认为是细胞内信使，但已经证明TRH刺激激素释放可以与环AMP浓度的变化分离，从而支持环AMP不是必需介质的论点。相反，TRH刺激激素释放需要Ca2+， Ca2+可能是TRH刺激与激素分泌之间的细胞内偶联因子。TRH已被证明可以刺激垂体预负荷细胞的45Ca2+外排。增强的45Ca2+外排被认为反映了导致激素释放的游离细胞内Ca2+浓度的增加；然而，Ca2 -的来源是不确定的。本文回顾了一系列垂体细胞实验的结果，这些实验试图确定受TRH影响的Ca2+池（或池）。这些包括：降低细胞外Ca2 -浓度对TRH刺激激素释放的影响；用金四环素监测TRH对细胞Ca2+的影响；TRH对Ca2+内流的影响；有机Ca2+通道阻滞剂维拉帕米和甲氧基维拉帕米对trh刺激激素释放的影响；TRH对细胞膜电位差和Ca2+依赖性动作电位的影响。基于这些数据，我们提出了关于乳腺和甲状腺激素释放中TRH刺激早期事件的不同假设。在乳腺检查中，TRH被认为通过仅动员细胞Ca2 -来提高游离细胞内Cat+浓度，从而刺激催乳素释放。相反，在正常生理条件下的促甲状腺激素中，TRH被认为通过从细胞池（或池）中动员Ca2来刺激TSH释放，并通过质膜中的电压依赖性通道诱导细胞外Ca2+的内流来增强这种作用。
SummaryThyrotropin releasing hormone (TRH) acutely stimulates release of thyrotropin (TSH) and prolactin from anterior pituitary cells. A considerable number of studies have been performed with neoplastic and nonneoplastic pituitary cells in culture to elucidate the sequence of intracellular events involved in this action. Although cyclic AMP was suggested as an intracellular messenger, it has been demonstrated that TRH stimulation of hormone release can be dissociated from changes in cyclic AMP concentration, thereby supporting the contention that cyclic AMP is not a required mediator. In contrast, stimulation of hormone release by TRH requires Ca2+ and it seems likely that Ca2+ is the intracellular coupling factor between TRH stimulation and hormone secretion. TRH has been shown to stimulate 45Ca2+ efflux from preloaded pituitary cells. Enhanced 45Ca2+ efflux is thought to reflect an increase in the free intracellular Ca2+ concentration which leads to hormone release; however, the source of this Ca2− is uncertain. Results are reviewed from a series of experiments in pituitary cells which attempt to determine the pool (or pools) of Ca2+ that is affected by TRH. These include the following: the effects of decreasing the extracellular Ca2− concentration on hormone release stimulated by TRH; the effect of TRH on cellular Ca2+ as monitored by chlortetracycline; the effects of TRH on Ca2+ influx; the effects of the organic Ca2+ channel blocking agents, verapamil and methoxyverapamil, on TRH-stimulated hormone release; and the effects of TRH on plasma membrane potential difference and on Ca2+-dependent action potentials. Based on these data, separate hypotheses of the early events in TRH stimulation of hormone release in mammotropes and thyrotropes are proposed. In mammotropes, TRH is thought to stimulate prolactin release optimally by elevating the free intracellular Cat+ concentration by mobilizing cellular Ca2− only. In contrast, in thyrotropes under normal physiological conditions, TRH is thought to stimulate TSH release by mobilizing Ca2 from a cellular pool (or pools) and to augment this effect by also inducing influx of extracellular Ca2+ through voltage-dependent channels in the plasma membrane.
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三氟拉嗪、D600 和苯妥英对去极化和促甲状腺素释放激素诱导的大鼠垂体组织促甲状腺素释放的影响。
影响因子：
4.8
作者：
Fleckman,A;Erlichman,J;Schubart,UK;Fleischer,N
通讯作者：
Fleischer,N
证据表明 Ca 在 3,5,3-三碘甲状腺原氨酸抑制促甲状腺素释放激素诱导的体外大鼠垂体前叶促甲状腺素分泌中可能发挥作用。
影响因子：
4.8
作者：
Schrey,MP;Larsen,PR
通讯作者：
Larsen,PR
受体介导的质膜相关钙的释放以及培养的垂体细胞中促甲状腺素释放激素刺激钙的吸收。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Tan,KN;TashjianJr,AH
通讯作者：
TashjianJr,AH
促甲状腺激素生物合成。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chin,WW;Maloof,F;Habener,JF
通讯作者：
Habener,JF