Synthesis of an antitumor active endoperoxide from 11-keto-β-boswellic acid
Synthesis of an antitumor active endoperoxide from 11-keto-β-boswellic acid
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DOI：
10.1016/j.ejmech.2010.05.036
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发表时间：
2010-09-01
影响因子：
6.7
通讯作者：
Stroehl, Dieter
中科院分区：
文献类型：
--
作者：
Csuk, Rene;Niesen-Barthel, Anja;Stroehl, Dieter
从11-酮基-β-乳香酸开始合成内过氧化物，并通过SRB测定在一组15个人癌细胞系中筛选抗肿瘤活性。该化合物诱导细胞凋亡并显示平均IC（50）值为0.4-4.5 μ M。(C)2010年Elsevier Masson SAS。All rights reserved.
An endoperoxide was synthesized starting from 11-keto-beta-boswellic acid and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The compound induces apoptosis and shows an average IC(50) value of 0.4-4.5 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.