Behavioral abnormality and pharmacologic response in social isolation-reared mice
Behavioral abnormality and pharmacologic response in social isolation-reared mice
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DOI：
10.1016/j.bbr.2009.03.028
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发表时间：
2009-08-24
影响因子：
2.7
通讯作者：
Yamada, Kiyofumi
中科院分区：
文献类型：
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作者：
Koike, Hiroyuki;Ibi, Daisuke;Yamada, Kiyofumi
在啮齿动物中饲养社会隔离(SI)会导致多种行为变化，包括多动症、焦虑、冲动、攻击性和学习记忆障碍。啮齿动物的这些行为异常可能与神经精神障碍患者的症状有关，如注意力缺陷多动障碍、强迫症、自闭症、精神分裂症和抑郁症。在这项研究中，我们研究了断奶后长期SI饲养对小鼠情绪行为和认知功能的影响。此外，考察了哌甲酯(MPH)、氯氮平(CLZ)和氟西汀(FIX)对SI诱导的行为改变的影响，以衡量SI饲养的小鼠作为这些神经精神障碍动物模型的预测有效性。在高架加迷宫测试中，PMH改善了SI诱导的焦虑样行为，但对攻击行为没有影响。相反，CLZ改善了SI饲养的小鼠的攻击行为，但没有改善焦虑样行为。反复固定治疗可防止SI引起的攻击性行为和社会互动缺陷。这些结果表明，SI诱发的行为异常是一种与神经精神障碍的各种临床症状相关的心理行为复合体，SI饲养的小鼠是研究这些疾病的病理生理/发病机制的有用的动物模型。(C)2009爱思唯尔B.V.保留所有权利。
Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuro psychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ)and fluoxetine (FIX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FIX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuro psychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases. (c) 2009 Elsevier B.V. All rights reserved.