Brain perfusion correlates of visuoperceptual deficits in mild cognitive impairment and mild Alzheimer's disease.
Brain perfusion correlates of visuoperceptual deficits in mild cognitive impairment and mild Alzheimer's disease.
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DOI：
10.3233/jad-2010-091069
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Tárraga L
中科院分区：
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作者：
Alegret M;Vinyes-Junqué G;Boada M;Martínez-Lage P;Cuberas G;Espinosa A;Roca I;Hernández I;Valero S;Rosende-Roca M;Mauleón A;Becker And JT;Tárraga L
阿尔茨海默病(AD)临床病程早期，视知觉加工受损。15个对象测试(15-OT)检测轻度认知障碍(MCI)和轻度AD的这种细微的表现缺陷。在早期AD和MCI患者中，已经发现颞叶、顶叶和前额叶区域的脑灌注量减少。目的：探讨15-OT在诊断MCI和AD中的作用，并探讨MCI、AD和正常老年人视觉功能障碍(15-OT)的脑血流灌注相关性。42例AD、42例MCI和42例健康老年对照(EC)受试者接受了脑单光子发射断层扫描(SPECT)，并分别完成了15-OT。方差分析比较了两组间15-OT得分。SPECT数据采用SPM5统计软件进行统计分析。MCI和AD患者的15-OT表现受损。在SPECT扫描方面，AD患者表现为颞顶区的血流灌注减少，而MCI患者的中间和后扣带回的血流灌注减少。当MCI组和AD组进行比较时，发现在颞顶区有显著的脑血流灌注减少。在整个样本中，15-OT表现与临床痴呆评分显著相关，与双侧后扣带回和右侧颞极的血流灌注显著相关，但在每一单独的组中没有显著相关性。我们的研究结果表明，15-OT表现提供了从正常衰老到AD的有用的损害分级，似乎与双侧后扣带回和右侧颞极的血流灌注有关。
Visuoperceptual processing is impaired early in the clinical course of Alzheimer’s disease (AD). The 15-Objects Test (15-OT) detects such subtle performance deficits in Mild Cognitive Impairment (MCI) and mild AD. Reduced brain perfusion in the temporal, parietal and prefrontal regions have been found in early AD and MCI patients. To confirm the role of the 15-OT in the diagnosis of MCI and AD, and to investigate the brain perfusion correlates of visuoperceptual dysfunction (15-OT) in subjects with MCI, AD and normal aging. Forty-two AD, 42 MCI and 42 healthy elderly control (EC) subjects underwent a brain Single Photon Emission Tomography (SPECT) and separately completed the 15-OT. An analysis of variance compared 15-OT scores between groups. SPM5 was used to analyse the SPECT data. 15-OT performace was impaired in the MCI and AD patients. In terms of the SPECT scans, AD patients showed reduced perfusion in temporal-parietal regions, while the MCI subjects had decreased perfusion in the middle and posterior cingulate. When MCI and AD groups were compared, a significant brain perfusion reduction was found in temporo-parietal regions. In the whole sample, 15-OT performance was significantly correlated with the clinical dementia rating scores, and with the perfusion in the bilateral posterior cingulate and the right temporal pole, with no significant correlation in each separate group. Our findings suggest that the 15-OT performance provides a useful gradation of impairment from normal aging to AD, and it seems to be related to perfusion in the bilateral posterior cingulate and the right temporal pole.