Fat and inflammation: adipocyte-myeloid cell crosstalk in atherosclerosis.

Fat and inflammation: adipocyte-myeloid cell crosstalk in atherosclerosis.
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脂肪和炎症:动脉粥样硬化中脂肪细胞-髓样细胞的相互作用。

DOI:
10.3389/fimmu.2023.1238664
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发表时间:
2023
影响因子:
7.3
通讯作者:
Koltsova, Ekaterina K.
Koltsova, Ekaterina K.
中科院分区:
医学2区
文献类型:
--
作者:
Mazitova, Aleksandra M.;Marquez-Sanchez, Ana Cristina;Koltsova, Ekaterina K.

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脂肪组织炎症与各种慢性炎症性疾病和癌症有关。血管周围脂肪组织(PVAT)作为额外的一层包裹在主动脉周围,被认为有助于动脉粥样硬化的发展。PVAT调节主动脉内皮和血管平滑肌细胞的功能,并代表可能参与主动脉炎症的各种免疫细胞的储存库。最近的研究表明,脂肪细胞也表达多种细胞因子受体,因此可能直接对炎症刺激作出反应。本文将对免疫机制调控脂肪细胞活化以及骨髓细胞与脂肪细胞在动脉粥样硬化发病机制中的相互作用进行综述。
Adipose tissue inflammation has been implicated in various chronic inflammatory diseases and cancer. Perivascular adipose tissue (PVAT) surrounds the aorta as an extra layer and was suggested to contribute to atherosclerosis development. PVAT regulates the function of endothelial and vascular smooth muscle cells in the aorta and represent a reservoir for various immune cells which may participate in aortic inflammation. Recent studies demonstrate that adipocytes also express various cytokine receptors and, therefore, may directly respond to inflammatory stimuli. Here we will summarize current knowledge on immune mechanisms regulating adipocyte activation and the crosstalk between myeloid cells and adipocytes in pathogenesis of atherosclerosis.
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