The comorbidity of adult attention-deficit/hyperactivity disorder in bipolar disorder patients
The comorbidity of adult attention-deficit/hyperactivity disorder in bipolar disorder patients
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DOI：
10.1016/j.comppsych.2012.11.005
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发表时间：
2013-07-01
影响因子：
7.3
通讯作者：
Atik, Levent
中科院分区：
文献类型：
--
作者：
Karaahmet, Elif;Konuk, Numan;Atik, Levent
目的：文献报道双相情感障碍（BMD）与轴I和轴II诊断的高共病率。注意力缺陷多动障碍（ADHD）与骨密度之间的可能关系在所有年龄组中引起了研究人员的更多关注，这是由于过度说话、注意力缺陷和运动活动增加等症状高度重叠。在本研究中，我们的目的是调查ADHD在BMD患者中的患病率和这些患者的临床特征。在2008年8月1日至2009年6月31日期间到宗古尔达克卡拉马斯大学研究和应用医院双相情感障碍科就诊并根据DSM-IV标准连续诊断为BMD的142例患者中，118例患者签署了知情同意书，其中90例完成了研究。在研究评价期间，所有受试者均处于正常胸腺期。一个社会人口学数据表，温德犹他州评级量表（WURS），ADD/ADHD诊断和评估量表的成人，和结构临床访谈DSM-IV轴I障碍，临床版本（SCID-I）被应用到所有参与patients.Results：共23.3%的所有患者符合标准的A-ADHD诊断沿着BMD。BMD+A-ADHD组和BMD无A-ADHD组之间的社会人口学特征无差异。BMD+A-ADHD组至少比对照组多受一年教育，差异有统计学意义。与无ADHD的BMD组相比，BMD + A-ADHD组的BMD开始年龄明显更早（p=0.044），并且BMD+A-ADHD组的躁狂发作次数更频繁（p=0.026）。BMD+A-ADHD组的惊恐障碍（p=0.019）和BMD+C-ADHD组的强迫症（p=0.001）是最常见的合并症。它与BMD的早期开始年龄、BMD过程中躁狂发作的数量较高以及合并有较多的Axis I诊断相关。(C)2013 Elsevier Inc. All rights reserved.
Objective: High comorbidity ratio of bipolar mood disorder (BMD) with Axis I and Axis II diagnoses is reported in the literature. The possible relationship between BMD and attention-deficit/hyperactivity disorder (ADHD) in all age groups has been attracting more attention of researchers due to highly overlapping symptoms such as excessive talking, attention deficit, and increased motor activity. In this study, we aimed to investigate the prevalence of ADHD cornorbidity in BMD patients and the clinical features of these patients.Methods: Of 142 patients, who presented to the Bipolar Disorder Unit of Zonguldak Karaelmas University Research and Application Hospital between the dates of August 1, 2008 and June 31, 2009 and diagnosed with BMD according to DSM-IV criteria consecutively, 118 patients signed informed consent and 90 of them completed the study. They all were in euthymic phase during the study evaluations. A sociodemographical data form, Wender-Utah Rating Scale (WURS), ADD/ADHD Diagnostic and Evaluation Inventory for Adults, and Structural Clinical Interview for DSM-IV Axis I Disorders, Clinical Version (SCID-I) were applied to all participating patients.Results: A total of 23.3% of all patients met the criteria for A-ADHD diagnosis along BMD. No difference was detected regarding sociodemographical features between the BMD+A-ADHD and the BMD without A-ADHD groups. The BMD+A-ADHD group had at least one extra educational year repetition than the other group and the difference was statistically significant. The BMD starting age in the BMD+A-ADHD group was significantly earlier (p=0.044) and the number of manic episodes was more frequent in the BMD+A-ADHD group (p=0.026) than the BMD without ADHD group. Panic disorder in the BMD+A-ADHD group (p=0.019) and obsessive-compulsive disorder in the BMD+C-ADHD group (p=0.001) were most frequent comorbidities.Conclusions: A-ADHD is a frequent comorbidity in BMD. It is associated with early starting age of BMD, higher number of manic episodes during the course of BMD, and more comorbid Axis I diagnoses. (C) 2013 Elsevier Inc. All rights reserved.