Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system - The Framingham heart study
Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system - The Framingham heart study
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DOI：
10.1161/circulationaha.107.731794
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发表时间：
2008-03-04
期刊：
影响因子：
37.8
通讯作者：
Aviv, Abraham
中科院分区：
文献类型：
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作者：
Vasan, Ramachandran S.;Demissie, Serkalem;Aviv, Abraham
背景-白细胞端粒长度(LTL)记录了生命过程中氧化应激和炎症的累积负担。肾素-血管紧张素-醛固酮系统的激活与氧化应激和炎症的增加有关。因此，LTL可能与肾素-血管紧张素-醛固酮系统的循环生物标志物有关。方法和结果-我们在1203名Framingham研究参与者(平均年龄59岁；51%的女性)中评估了LTL(因变量)与循环肾素和醛固酮浓度以及肾素/醛固酮比率(均为对数转换；自变量)的横截面关系。我们使用了多变量线性回归，并调整了年龄、血压、高血压治疗、吸烟、糖尿病、体重指数、激素替代治疗、血肌酐和尿钠/肌酐比率。总体而言，多变量调整后的LTL与肾素呈负相关(每单位增加的β系数为-0.038；P=0.036)，与醛固酮呈正相关(β=0.099；P=0.002)，与肾素/醛固酮比值呈负相关(β=0.049；P=0.003)。LTL与生物标记物的关系在高血压患者中更强，尽管交互作用的正式检验没有统计学意义(P=0.20)。高血压患者LTL与肾素(β=0.060；P=0.005)、醛固酮(β=0.134；P=0.002)、肾素/醛固酮比值(β=0.072；P=0.001)显著相关。肾素/醛固酮比值在前三分位数的高血压患者的LTL比最低三分位数的患者短182个碱基对。结论：在我们的社区样本中，肾素/醛固酮比率较高的个体的LTL较短，特别是在高血压患者中。有必要进行更多的调查以证实我们的观察结果。
Background-Leukocyte telomere length (LTL) chronicles the cumulative burden of oxidative stress and inflammation over a life course. Activation of the renin-angiotensin-aldosterone system is associated with increased oxidative stress and inflammation. Therefore, LTL may be related to circulating biomarkers of the renin-angiotensin-aldosterone system.Methods and Results-We evaluated the cross-sectional relations of LTL (dependent variable) to circulating renin and aldosterone concentrations and the renin-to-aldosterone ratio (all logarithmically transformed; independent variables) in 1203 Framingham Study participants (mean age, 59 years; 51% women). We used multivariable linear regression and adjusted for age, blood pressure, hypertension treatment, smoking, diabetes mellitus, body mass index, hormone replacement therapy, serum creatinine, and the urine sodium-to-creatinine ratio. Overall, multivariable-adjusted LTL was inversely related to renin (beta coefficient per unit increase, -0.038; P=0.036), directly related to aldosterone (beta=0.099; P=0.002), and inversely related to the renin-to-aldosterone ratio (beta=0.049; P=0.003). Relations of LTL to biomarkers were stronger in those with hypertension, although a formal test of interaction was not statistically significant (P=0.20). Individuals with hypertension displayed significant associations of LTL with renin (beta=0.060; P=0.005), aldosterone (beta=0.134; P=0.002), and renin-to-aldosterone ratio (beta= 0.072; P=0.001). Participants with hypertension who were in the top tertile of the renin-to-aldosterone ratio had LTL that was 182 base pairs shorter relative to those in the lowest tertile.Conclusions-In our community-based sample, LTL was shorter in individuals with a higher renin-to-aldosterone ratio, especially in participants with hypertension. Additional investigations are warranted to confirm our observations.