The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics:: agricultural, chemical and clinical aspects
The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics:: agricultural, chemical and clinical aspects
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DOI：
10.1016/s0378-8741(00)00289-0
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发表时间：
2000-12-01
影响因子：
5.4
通讯作者：
Wemakor, E
中科院分区：
文献类型：
--
作者：
Mueller, MS;Karhagomba, IB;Wemakor, E
植物青蒿（菊科）被《中国药典》列为治疗包括疟疾在内的各种发烧的药物，并含有成熟的抗疟化合物青蒿素。在这项研究中，青蒿的杂交品种在中非成功培育。该植物的地上部分每干重含有0.63-0.70%的青蒿素，并且通过简单的制茶方法可以提取大约40%的青蒿素。 5 名疟疾患者接受青蒿茶治疗后，寄生虫血症在 2-4 天内迅速消失。另一项对 48 名疟疾患者进行的试验显示，4 天内 44 名患者（92%）的寄生虫血症消失。两项试验均显示症状明显改善。我们认为，这些结果证明有必要进一步检查青蒿制剂的抗疟作用。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
The plant Artemisia annua L. (Asteraceae) is listed in the Chinese pharmacopoeia as a remedy for various fevers including malaria, and contains the well-established antimalarial compound artemisinin. In this study, a hybrid form of A. annua was successfully cultivated in Central Africa. The aerial parts of the plant contained 0.63-0.70% artemisinin per dry weight, and approximately 40% of this artemisinin could be extracted by simple tea preparation methods. Five malaria patients who were treated with A. annua tea showed a rapid disappearance of parasitaemia within 2-4 days. An additional trial with 48 malaria patients showed a disappearance of parasitaemia in 44 patients (92%) within 4 days. Both trials showed a marked improvement of symptoms. In our opinion, these results justify further examinations of the antimalarial effect of A. annua preparations. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.