Visual contrast sensitivity in major depressive disorder
Visual contrast sensitivity in major depressive disorder
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DOI：
10.1016/j.jpsychores.2013.03.008
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发表时间：
2013-07-01
影响因子：
4.7
通讯作者：
Luu, Chi
中科院分区：
文献类型：
--
作者：
Fam, Johnson;Rush, A. John;Luu, Chi
目的：在抑郁症患者眼中，世界可能会显得沉闷和灰暗。最近有报道称，抑郁症患者的视觉对比敏感度低于健康对照组。我们的目的是检查这一发现的一致性，并探讨潜在的视网膜电生理。方法：选取20例重度抑郁症患者和20例健康对照。采用视网膜电图（PERG）和主观视觉对比试验评估视觉对比敏感度。此外，还使用全场视网膜电图（ffERG）评估视网膜神经生理学。根据精神疾病诊断与统计手册（DSM-IV）诊断抑郁症，使用标准心理测量量表测量抑郁症的严重程度。结果：基于Landolt C视觉对比测试，抑郁症患者的视觉对比敏感度明显低于对照组，但使用PERG和ffERG的组间无差异。抑郁症状的严重程度越高，视觉对比敏感度越低（r = 0.49, p = 0.001）。结论：抑郁症受试者的视觉对比辨别能力下降，但这一发现不能用PERG一致地确定。重度抑郁症和视觉对比敏感性之间的神经生物学联系值得进一步研究。(C) 2013爱思唯尔公司版权所有。
Objective: Through the eyes of those depressed, the world may appear dull and gray. Visual contrast sensitivity has recently been reported to be lower in depressed patients compared to healthy controls. We aimed to examine the consistency of this finding and to explore the underlying retinal electrophysiology.Methods: Twenty subjects with major depressive disorder and 20 matched healthy controls were studied. Pattern electroretinogram (PERG) and subjective visual contrast test were used to assess visual contrast sensitivity. Full-field electroretinography (ffERG) was additionally used to assess retinal neurophysiology. Depression was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and depression severity was measured using standard psychometric scales.Results: Visual contrast sensitivity was significantly lower in depressed patients compared to controls based on the Landolt C visual contrast test, but no difference was found between groups using PERG and ffERG. Greater severity of depressive symptoms correlated (r = 0.49, p = 0.001) with poorer visual contrast sensitivity.Conclusions: Depressed subjects had reduced visual contrast discrimination performance, but this finding could not be consistently determined using PERG. The neurobiological link between major depressive disorder and visual contrast sensitivity warrants further investigation. (C) 2013 Elsevier Inc. All rights reserved.