Alpha-synuclein and autophagy as common steps in neurodegeneration.
Alpha-synuclein and autophagy as common steps in neurodegeneration.
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DOI：
10.1016/j.parkreldis.2008.04.025
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发表时间：
2008-01-01
影响因子：
4.1
通讯作者：
Fornai, Francesco
中科院分区：
文献类型：
--
作者：
Ferrucci, Michela;Pasquali, Livia;Fornai, Francesco
The major component of Lewy bodies in Parkinson's disease (PD) is alpha-synuclein, which is considered as a substrate of the ubiquitin-proteasome (UP) system, although autophagy seems to be equally involved. Here we discuss the co-existence of alpha-synuclein and proteins belonging to the UP system within autophagic granules, further developing as neuronal inclusions. We hypothesize that, following slight insults, both UP and autophagy are induced; if toxic stimuli are prolonged, these pathways are overwhelmed and cell death occurs. We then indicate a protective role of autophagy in PD and suggest it as a therapeutic target to slow down the progression of the disease.
