Influence of gender on control of arterial tone in experimental hypertension
Influence of gender on control of arterial tone in experimental hypertension
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DOI：
10.1152/ajpheart.1998.275.1.h15
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发表时间：
1998-07-01
影响因子：
4.8
通讯作者：
Pörsti, I
中科院分区：
文献类型：
--
作者：
Kähönen, M;Tolvanen, JP;Pörsti, I
雌性自发性高血压大鼠（SHR）的内皮功能障碍较雄性轻，这可能是SHR高血压进展程度和速率存在性别差异的原因。然而，性别对不同内皮源性介质在高血压动脉反应中的作用的影响尚未详细评估。因此，在雌性和雄性自发性高血压大鼠（SHR）的肠系膜动脉环在体外的收缩和舒张反应进行了研究，与正常血压的雌性和雄性Wistar-Kyoto大鼠（WKY）作为对照。在去甲肾上腺素（NE）预收缩的动脉环，内皮依赖性舒张ACh以及内皮非依赖性舒张硝普钠在女性比男性SHR更明显，而舒张P-肾上腺素受体激动剂异丙肾上腺素仍然同样受损的女性和男性SHR。环氧合酶抑制剂双氯芬酸，这减少了合成的扩张和收缩的前列腺素，显着增强舒张ACh在雄性SHR，但不是在其他组。NO合成酶抑制剂N-G-硝基-L-精氨酸甲酯（N-G-nitro-L-arginine methyl ester，N-G-nitro-L-arginine methyl ester，N-G-nitro-L-arginine methyl ester，N-G-nitro-L-arginine methyl ester）对雌性SHR和WKY的ACh舒张作用的抑制作用明显强于雄性SHR和WKY。然而，当内皮依赖性超极化被阻止预收缩的准备与氯化钾，没有显着差异，发现在研究组之间的ACh松弛。总之，释放环氧合酶衍生的收缩因子似乎是更明显的男性比女性SHR。此外，NO在内皮依赖性动脉舒张中的相对作用似乎在雌性SHR中高于雄性SHR，并且由NO供体诱导的舒张在雌性SHR中也比在雄性SHR中更明显。
Endothelial dysfunction has been found to be less severe in female than in male spontaneously hypertensive rats (SHR), which could contribute to the gender differences observed in the extent and rate of progression of hypertension in SHR. However, the influence of gender on the roles of different endothelium-derived mediators in the arterial responses in hypertension have not been evaluated in detail. Therefore, contractile and relaxation responses of mesenteric arterial rings in vitro were studied in female and male SHR, with normotensive female and male Wistar-Kyoto rats (WKY) serving as controls. In norepinephrine (NE)-precontracted arterial rings, endothelium-dependent relaxations to ACh as well as endothelium-independent dilations to sodium nitroprusside were more pronounced in female than in male SHR, whereas relaxations to the P-adrenoceptor agonist isoproterenol remained equally impaired in female and male SHR. The cyclooxygenase inhibitor diclofenac, which reduces the synthesis of dilating and constricting prostanoids, markedly enhanced the relaxations to ACh in male SHR but not in the other groups. The nitric oxide (NO) synthase inhibitor N-G-nitro-L-arginine methyl ester attenuated the relaxations to ACh more effectively in female SHR and WKY than in the male groups. However, when endothelium-dependent hyperpolarization was prevented by precontracting the preparations with KCl, no significant differences were found in relaxations to ACh among the study groups. In conclusion, release of cyclooxygenase-derived constricting factors appeared to be more pronounced in male than in female SHR. In addition, the relative role of NO in endothelium-dependent arterial relaxation seemed to be higher in female than in male SHR, and relaxation induced by an NO donor also was more pronounced in female than in male SHR.