The homeotic target gene centrosomin encodes an essential centrosomal component
The homeotic target gene centrosomin encodes an essential centrosomal component
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DOI：
10.1016/s0092-8674(00)81258-1
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发表时间：
1996-05-17
期刊：
影响因子：
64.5
通讯作者：
Kaufman, TC
中科院分区：
文献类型：
--
作者：
Li, KJ;Kaufman, TC
中心体蛋白 (cnn) 基因编码与果蝇有丝分裂中心体相关的蛋白质，是同源异型基因调控的目标。在这里，我们报告 CNN 是中心体的重要组成部分。合子 cnn 表达的丧失会扰乱第二中肠收缩、胃盲肠和神经系统的发育。缺乏母体和合子 cnn 表达的胚胎在核分裂、染色体排列和微管组织方面表现出缺陷，而 cnn(-) 细胞镶嵌的成年果蝇则表现出表明细胞增殖受阻的缺陷。我们认为 cnn 提供了同源基因直接调节必需细胞蛋白积累以执行片段特异性形态发生功能的一个例子。
The centrosomin (cnn) gene encodes a protein associated with mitotic centrosomes in Drosophila melanogaster and is a target of homeotic gene regulation. Here we report that CNN is an essential component of the centrosome. Loss of zygotic cnn expression disrupts the development of the second midgut constriction, the gastric caeca, and the nervous system. Embryos that lack maternal as well as zygotic cnn expression display defects in nuclear division, chromosome alignment, and microtubule organization, while adult flies that are mosaic for cnn(-) cells exhibit defects indicative of a block in cell proliferation. We propose that cnn provides an example of homeotic genes directly regulating the accumulation of essential cellular proteins to carry out segment-specific morphogenetic functions.