A PREFECTURE-WIDE SURVEY OF MUMPS MENINGITIS ASSOCIATED WITH MEASLES, MUMPS AND RUBELLA VACCINE
A PREFECTURE-WIDE SURVEY OF MUMPS MENINGITIS ASSOCIATED WITH MEASLES, MUMPS AND RUBELLA VACCINE
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DOI：
10.1097/00006454-199103000-00007
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发表时间：
1991-03-01
影响因子：
3.6
通讯作者：
KUROUME, T
中科院分区：
文献类型：
--
作者：
FUJINAGA, T;MOTEGI, Y;KUROUME, T
在日本群马县，在4名患者因无菌性脑膜炎住院后不久，对接种新引进的麻疹、腮腺炎和风疹（MMR）疫苗后的不良反应，特别是中枢神经系统反应进行了调查。 在1989年4月至11月的8个月期间，接种MMR疫苗后2个月内，分别有35名、6名和2名儿童发生脑膜炎、惊厥性疾病和腮腺炎。 在35例脑膜炎病例中，MMR疫苗接种与脑膜炎之间的时间间隔为14至28天。 从13例无菌性脑膜炎患者的脑脊液中分离到腮腺炎病毒，通过测定腮腺炎疫苗株P基因的核苷酸序列来鉴定其特征。 流行性腮腺炎疫苗病毒阳性的无菌性脑膜炎的发病率在4月至11月的8个月期间估计为0.11%（整体为0.3%），在9月和10月增加到0.3%（整体为0.7%）。 我们的结论是，MMR疫苗接种后无菌性脑膜炎的发病率似乎高于以前报道的。
A survey of untoward reactions, especially central nervous system reactions, after the administration of a newly introduced measles, mumps and rubella (MMR) vaccine in Gunma Prefecture, Japan, was initiated soon after 4 patients were hospitalized for aseptic meningitis. Thirty-five, 6 and 2 children developed meningitis, convulsive disorders and parotitis, respectively, within 2 months after MMR vaccination during the 8-month period extending from April to November, 1989. The time lag between MMR vaccination and meningitis ranged from 14 to 28 days in the 35 cases of meningitis. Mumps virus, isolated from the cerebrospinal fluid in 13 patients with aseptic meningitis, was characterized by determination of the nucleotide sequences of the P gene as mumps vaccine strain. The incidence of aseptic meningitis with positive mumps vaccine virus was estimated to be 0.11% (0.3% as a whole) during the 8 months from April to November and increased to 0.3% (0.7% as a whole) in September and October. We conclude that the incidence of aseptic meningitis after MMR vaccination seems to be higher than that reported previously.