C-type lectin receptors in antifungal immunity.
C-type lectin receptors in antifungal immunity.
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DOI：
10.1016/j.tim.2007.10.012
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发表时间：
2008
影响因子：
15.9
通讯作者：
J. Willment;Gordon D. Brown
中科院分区：
文献类型：
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作者：
J. Willment;Gordon D. Brown
真菌感染是一种严重的健康负担，特别是在免疫功能低下的人中，但许多涉及识别和控制这些病原体的潜在免疫学机制尚不清楚。Toll样受体(Toll-like Receptor，TLRs)的发现为微生物的先天识别和免疫应答的启动提供了新的思路；然而，最近的证据表明，非TLR受体在这些过程中也有重要作用，特别是在抗真菌免疫中。有趣的是C型凝集素受体家族的成员，包括甘露糖受体，树突状细胞特异性细胞间黏附分子-3(ICAM-3)-抓取非整合素(DC-SIGN)，Dectin-1，Dectin-2和集合素。在这里，我们回顾了这些受体中的每一个的作用，描述了它们如何有助于真菌的识别、摄取和杀伤，以及如何参与诱导和/或调节宿主免疫反应。
Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of immune responses; however, recent evidence indicates that the ‘non-TLR' receptors also have a significant role in these processes, particularly in antifungal immunity. Of interest are members of the C-type lectin-receptor family, including the mannose receptor, dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3)-grabbing non-integrin (DC-SIGN), Dectin-1, Dectin-2 and the collectins. Here, we review the roles of each of these receptors, describing how they contribute to fungal recognition, uptake and killing and also participate in the induction and/or modulation of the host immune response.