The systemic inflammatory response to cardiopulmonary bypass.
The systemic inflammatory response to cardiopulmonary bypass.
复制标题
DOI：
10.1016/s0889-8537(03)00039-7
复制
发表时间：
2003-09-01
期刊：
影响因子：
--
通讯作者：
Collard, Charles D
中科院分区：
文献类型：
--
作者：
Pintar, Tatjana;Collard, Charles D
尽管我们对CPB全身性炎症反应的基本病理生理学的理解在过去20年中有了显著的进展，但这些实验得出的观点尚未完全融入临床实践。对CPB的全身炎症反应的治疗也因炎症抑制可能破坏保护性生理反应或导致免疫抑制而混淆。虽然单一的治疗策略不太可能足以完全预防cpb相关的发病率，但多种药理学和机械治疗策略的结合，每种策略都有选择地针对炎症反应的不同组成部分，最终可能会显著改善心脏手术后的临床结果。
Although our understanding of the basic pathophysiology of systemic inflammatory response to CPB has significantly advanced in the last 2 decades, these experimentally derived ideas have yet to be fully integrated into clinical practice. Treatment of the systemic inflammatory response to CPB is also confounded by the fact that inhibition of inflammation might disrupt protective physiologic responses or result in immunosuppression. Although it is unlikely that no single therapeutic strategy will ever be sufficient in of itself to totally prevent CPB-associated morbidity, the combination of multiple pharmacologic and mechanical therapeutic strategies, each selectively targeted at different components of the inflammatory response, may eventually result in significantly improved clinical outcomes following cardiac surgery.