Requirements for DI particle prophylaxis against vesicular stomatitis virus infection in vivo.
Requirements for DI particle prophylaxis against vesicular stomatitis virus infection in vivo.
复制标题
DI颗粒预防体内水疱性口炎病毒感染的要求。
DOI：
10.1099/0022-1317-49-1-215
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Holland,JJ
中科院分区：
文献类型：
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作者：
Jones,CL;Holland,JJ
与生物活性DI颗粒相比，u. v. -灭活的标准病毒也不是两种不同的同源u. v. -当脑内注射到同时用VSV攻击的小鼠中时，灭活的DI颗粒显示出任何预防效果。虽然UV-当与攻击病毒一起给予时，灭活的DI颗粒并不能阻止死亡，但它们确实显着延长了死亡发生的时间。另外，紫外线-灭活的标准病毒和DI颗粒保护小鼠免受后期攻击（在处理后3或10天）。两种不同活性DI颗粒的制剂的剂量滴定显示出对同时攻击的显著预防作用，其中DI颗粒的数量比当u. v.灭活因此，该系统中的预防需要具有生物活性的DI颗粒。
In contrast to biologically active DI particles, neither u.v.-inactivated standard virus nor either of two different homologous u.v.-inactivated DI particles showed any prophylactic effect when injected intracerebrally into mice concomitantly challenged with VSV. Although u.v.-inactivated DI particles did not prevent death when given with the challenge virus, they did significantly lengthen the time until death occurred. Also, both u.v.-inactivated standard virus and DI particles protected mice against late challenge (at 3 or 10 days after treatment). Dosage titrations of preparations of two different active DI particles showed significant prophylaxis against simultaneous challenge with numbers of DI particles 10- to 100-fold lower than those which gave no prophylaxis when u.v.-inactivated. Thus, prophylaxis in this system required biologically active DI particles.