Perceptual and attentional asymmetries in schizophrenia: Further evidence for a left hemisphere deficit
Perceptual and attentional asymmetries in schizophrenia: Further evidence for a left hemisphere deficit
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DOI：
10.1016/0165-1781(96)02849-1
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发表时间：
1996-05-17
影响因子：
11.3
通讯作者：
OshoraCelaya, L
中科院分区：
文献类型：
--
作者：
Carter, CS;Robertson, LC;OshoraCelaya, L
越来越多的证据表明精神分裂症存在侧化注意力缺陷。在本研究中，通过全局/局部任务对 23 名未接受药物治疗的精神分裂症患者（平均年龄 = 32.1 岁）和 14 名年龄和性别匹配的正常受试者进行了研究，以提供精神分裂症中左半球相关注意力缺陷存在的一致证据。这项任务对区分局部和全局刺激元素所涉及的机制的完整性很敏感。先前的研究已将局部目标的辨别与左半球过程联系起来，将全局目标的辨别与右半球过程联系起来。正如预测的那样，患者对局部目标的检测能力受到损害，这与左半球缺陷一致。损伤程度与患者的幻听水平相关。这些结果与先前的研究一致，显示精神分裂症和左半球功能障碍存在不对称注意力缺陷。这种缺陷与幻听之间的相关性与精神分裂症中这种症状与左颞病理之间的假设关系一致。
Increasing evidence suggests the presence of a lateralizing attentional deficit in schizophrenia. In the present study, 23 unmedicated patients with schizophrenia (mean age = 32.1 years) and 14 age- and sex-matched normal subjects were studied with the Global/Local Task to provide converging evidence for the presence of a left-hemisphere-associated attentional deficit in schizophrenia. This task is sensitive to the integrity of mechanisms involved in discriminating local and global elements of stimuli. Previous research has linked the discrimination of local targets to left hemispheric processes and the discrimination of global targets to right hemispheric processes. As predicted, patients were impaired in the detection of local level targets, consistent with a left hemispheric deficit. The degree of impairment correlated with the patient's level of auditory hallucinations. These results are consistent with previous studies showing an asymmetrical attentional deficit in schizophrenia and left hemispheric dysfunction. The correlation between this deficit and auditory hallucinations is consistent with a hypothesized relationship between this symptom in schizophrenia and left temporal pathology.