An evaporation-based disposable micropump concept for continuous monitoring applications
An evaporation-based disposable micropump concept for continuous monitoring applications
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DOI：
10.1023/a:1014215728074
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发表时间：
2002-03-01
影响因子：
2.8
通讯作者：
Krämer, P
中科院分区：
文献类型：
--
作者：
Effenhauser, CS;Harttig, H;Krämer, P
描述了一种廉价而简单的泵送原理，它能够在较长时间内(几天到几周)提供小流量和恒定流量(10-1,000毫升/分钟)。这一概念是基于液体通过膜控制蒸发进入含有吸着剂的气体空间。只要吸附剂将气相中的蒸汽压保持在饱和以下，从膜中蒸发的流体就会被诱导从储油层流动的毛细管力所取代。在一项可行性研究中，总体积为300mul的林格氏溶液被连续泵入6天，得到的恒定平均流速为35NL/分钟(590pl/S)。最大输液量受吸附容量和吸附剂用量的限制。低制造成本、高可靠性(无移动部件)、适合集成到平面系统架构中，以及除了可调节温度的环境外，缺乏特殊的外部能源是该概念的重要特征，特别是在连续患者监护方面的潜在应用。与导致不连续、脉冲式流动的许多其他泵机构相比，可以实现真正的连续流动。对于更广泛的应用来说，一个挑战是流量固有的温度依赖性。在目前的版本中，该泵只能在吸气模式下使用。
An inexpensive and simple pumping principle is described that is capable of delivering both small and constant flow rates (10-1,000 nl/min) over a longer period of time (days to weeks). The concept is based on controlled evaporation of a liquid through a membrane into a gas space containing a sorption agent. As long as the sorption agent keeps the vapor pressure in the gas phase below saturation, fluid evaporated from the membrane is replaced by capillary forces inducing flow from a reservoir. In a feasibility study, a total volume of 300 mul of Ringer's solution has been continuously pumped over a period of six days, resulting in an constant average flow rate of 35 nl/min (590 pl/s). The maximum liquid volume transported is limited by sorption capacity and amount of the sorption agent. Low fabrication costs, high reliability (no moving parts), the suitability for integration into planar system architectures and the lack of a special external energy source besides an environment of regulated temperature are important features of the concept, in particular with regard to its potential application in continuous patient monitoring. Truly continuous flow can be achieved in contrast to many other pump mechanisms leading to discontinuous, pulse-type flow. A challenge for a broader range of applications is the inherent temperature dependence of the flow rate. In its current version, the pump can only be used in a suction-mode.