Extracorporeal Respiratory Support With a Miniature Integrated Pediatric Pump-Lung Device in an Acute Ovine Respiratory Failure Model
Extracorporeal Respiratory Support With a Miniature Integrated Pediatric Pump-Lung Device in an Acute Ovine Respiratory Failure Model
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在急性绵羊呼吸衰竭模型中使用微型集成儿科泵肺装置进行体外呼吸支持
DOI：
10.1111/aor.12705
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发表时间：
2016
影响因子：
2.4
通讯作者：
Wu Zhongjun J.
中科院分区：
文献类型：
--
作者：
Wei Xufeng;Sanchez Pablo G.;Liu Yang;Watkins A. Claire;Li Tieluo;Griffith Bartley P.;Wu Zhongjun J.
呼吸衰竭是全世界死亡和发病的主要原因之一。治疗呼吸衰竭的治疗选择仍然有限。本研究的目的是评价新开发的小型便携式集成儿科泵肺装置（PediPL）在急性绵羊呼吸衰竭模型中用于呼吸支持的气体输送性能。在6只成年绵羊中，使用静脉麻醉和减少机械通气2次/小时，通过手术植入PediPL装置，并在右心房和肺动脉之间的静脉-静脉配置中评价呼吸支持。在使用PediPL的装置气体传输性能支持期间，研究动物的血液动力学和呼吸状态4小时。在机械通气减少至2次呼吸/分钟后30分钟，动物表现出呼吸衰竭，表现为低氧分压、低氧饱和度和动脉血中二氧化碳升高。30分钟后，通过使用PediPL建立呼吸支持，可以逆转失败。PediPL的O2转移和CO2清除率分别为86.8和139.1 mL/min。结果表明，PediPL（微型集成泵氧合器）具有提供呼吸支持的潜力，可作为缺氧和高碳酸血症的新型治疗方法。PediPL的紧凑尺寸可以允许便携性，并有可能在许多紧急情况下用于抢救急性肺损伤患者。
Respiratory failure is one of the major causes of mortality and morbidity all over the world. Therapeutic options to treat respiratory failure remain limited. The objective of this study was to evaluate the gas transfer performance of a newly developed miniature portable integrated pediatric pump‐lung device (PediPL) with small membrane surface for respiratory support in an acute ovine respiratory failure model.The respiratory failure was created in six adult sheep using intravenous anesthesia and reduced mechanical ventilation at 2 breaths/min. The PediPL device was surgically implanted and evaluated for respiratory support in a venovenous configuration between the right atrium and pulmonary artery. The hemodynamics and respiratory status of the animals during support with the device gas transfer performance of the PediPL were studied for 4 h.The animals exhibited respiratory failure 30 min after mechanical ventilation was reduced to 2 breaths/min, indicated by low oxygen partial pressure, low oxygen saturation, and elevated carbon dioxide in arterial blood. The failure was reversed by establishing respiratory support with the PediPL after 30 min. The rates of O2transfer and CO2removal of the PediPL were 86.8 and 139.1 mL/min, respectively.The results demonstrated that the PediPL (miniature integrated pump‐oxygenator) has the potential to provide respiratory support as a novel treatment for both hypoxia and hypercarbia. The compact size of the PediPL could allow portability and potentially be used in many emergency settings to rescue patients suffering acute lung injury.