Neurobehavior at Term and White and Gray Matter Abnormalities in Very Preterm Infants
Neurobehavior at Term and White and Gray Matter Abnormalities in Very Preterm Infants
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DOI：
10.1016/j.jpeds.2009.01.038
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发表时间：
2009-07-01
影响因子：
5.1
通讯作者：
Doyle, Lex W.
中科院分区：
文献类型：
--
作者：
Brown, Nisha C.;Inder, Terrie E.;Doyle, Lex W.
目的 探讨极早产儿足月神经行为与并发磁共振定义的大脑异常之间的关系。研究设计 168 名极早产儿（出生体重 < 1250 g 或妊娠 < 30 周）在足月时接受了 2 项标准化神经行为评估、修订版 Hammersmith 新生儿神经学检查和新生儿重症监护室网络检查 神经行为量表。确定了综合神经行为评分与磁共振成像定性白质和灰质异常之间的关系。结果 较差的神经行为表现与磁共振定义的脑异常相关。综合神经行为评分与白质异常的总等级相关，而较差的神经行为与该等级的两个组成部分关系最密切：白质信号异常和白质体积减少。神经行为与灰质异常的总等级无关。然而，脑回成熟延迟（总灰质等级的一个组成部分）与两种神经行为量表的较差表现有关。 结论 足月时极早产儿的神经行为与定性磁共振成像定义的白质和灰质同时发生的大脑异常有关。 (J Pediatr 2009；155:32-8)。
Objective To examine the relationship between very preterm infant neurobehavior at term and concurrent magnetic resonance-defined cerebral abnormalities.Study design 168 very preterm infants (birth weight < 1250 g or gestation < 30 weeks) were examined at term with 2 standardized neurobehavioral assessments, the Revised Hammersmith Neonatal Neurological Examination and the Neonatal Intensive Care Unit Network Neurobehavioral Scale. The relationship between composite neurobehavioral scores and qualitative white and gray matter abnormalities on magnetic resonance imaging was determined.Results Poorer neurobehavioral performance related to magnetic resonance-defined cerebral abnormalities. Composite neurobehavioral scores related to the total grade of white matter abnormality, and worse neurobehavior related most strongly to 2 components of this grade: white matter signal abnormalities and reduction in white matter volumes. Neurobehavior was not related to the total grade of gray matter abnormality. However, delayed gyral maturation, a component of the total gray matter grade, was related to poorer performance on both neurobehavioral scales.Conclusion Very preterm infant neurobehavior at term is related to concurrent cerebral abnormalities in both white and gray matter defined by qualitative magnetic resonance imaging. (J Pediatr 2009;155:32-8).