Morphometric Diagnosis of Melanocytic Skin Tumors
Morphometric Diagnosis of Melanocytic Skin Tumors
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黑色素细胞皮肤肿瘤的形态测量诊断
DOI：
10.1097/00000372-199010000-00002
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
H. Kerl
中科院分区：
文献类型：
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作者：
Gerhard Leitinger;L. Cerroni;H. Soyer;J. Smolle;H. Kerl
通过检查连续采样的 206 个最大垂直直径至少为 1 mm 的黑素细胞病变（133 个良性真皮痣、20 个斯皮茨痣、53 个原发性恶性黑色素瘤）的常规切片，我们使用计算机辅助交互式图像分析系统测量了浅层和深层真皮肿瘤部分各至少 60 个细胞核的形态特征。此外，我们计算了每种情况下所谓的成熟参数（MP），即深层部分和浅层部分的平均核面积之比。当我们将结果与训练集中获得的结果进行比较时，我们发现区分良性和恶性黑素细胞病变的最低证据来自浅层核区域平均值的应用（效率 = 62.1%）。当我们使用深层核区域的平均值（96.1％）和成熟参数（85.4％）时，效率更高。通过同时应用深层平均核面积和成熟参数，我们在区分良性真皮痣和恶性黑色素瘤（0.968,0.955,1）以及区分斯皮茨痣和恶性黑色素瘤（0.986,0.950,1）方面获得了最高的效率、特异性和敏感性。我们的研究表明，形态测定法可以为常规取样的黑素细胞皮肤肿瘤提供可靠的诊断结果。
Checking consecutively sampled routine sections of 206 melanocytic lesions with a maximum vertical diameter of at least 1 mm (133 benign dermal nevi, 20 Spitz's nevi, 53 primary malignant melanomas), we measured the morphometric features of at least 60 nuclei each from the superficial and the deep dermal tumor portion using a computer-assisted interactive image analysis system. Furthermore we calculated the so-called maturation parameter (MP) in each case as the ratio of the mean nuclear area in the deep portion and the superficial portion. When we compared the results with those obtained in a training set, we found that the lowest evidence for the discrimination of benign and malignant melanocytic lesions resulted from the application of the mean values of the nuclear area in the superficial layer (efficiency = 62.1%). The efficiency was higher when we used the mean values of the nuclear area in the deep layer (96.1%) and the maturation parameter (85.4%). By applying the mean nuclear area in the deep portion and the maturation parameter simultaneously, we gained the highest efficiency, specificity, and sensitivity for the distinction between benign dermal nevi and malignant melanomas (0.968, 0.955, 1) as well as for the distinction between Spitz's nevi and malignant melanomas (0.986, 0.950, 1). Our study shows that morphometry provides reliable diagnostic results in routinely sampled melanocytic skin tumors.