Influencing factors on serum 25-hydroxyvitamin D3 levels in Japanese chronic hepatitis C patients.
Influencing factors on serum 25-hydroxyvitamin D3 levels in Japanese chronic hepatitis C patients.
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DOI：
10.1186/s12879-015-1020-y
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发表时间：
2015-08-19
影响因子：
3.7
通讯作者：
Iwakiri K
中科院分区：
文献类型：
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作者：
Atsukawa M;Tsubota A;Shimada N;Yoshizawa K;Abe H;Asano T;Ohkubo Y;Araki M;Ikegami T;Kondo C;Itokawa N;Nakagawa A;Arai T;Matsushita Y;Nakatsuka K;Furihata T;Chuganji Y;Matsuzaki Y;Aizawa Y;Iwakiri K
慢性丙型肝炎患者的血清 25-羟基维生素 D3 水平通常低于健康个体。本研究的目的是利用从日本慢性丙型肝炎患者获得的数据来阐明影响血清 25-羟基维生素 D3 水平的因素。研究对象为 619 名慢性丙型肝炎患者。 2009年4月至2014年8月期间，采用双抗体放射免疫法测定血清25-羟基维生素D3水平。血清25-羟基维生素D3水平在20ng/mL以下为维生素D缺乏，血清25-羟基维生素D3水平在30ng/mL以上为维生素D充足。分析患者相关因素与血清25-羟基维生素D3水平的关系。该队列由 305 名女性和 314 名男性组成，年龄在 18 岁至 89 岁之间（中位年龄 63 岁）。血清 25-羟基维生素 D3 的中位水平为 21 ng/mL（范围：6–61 ng/mL）。另一方面，健康受试者的血清 25-羟基维生素 D3 中位水平为 25 ng/mL（范围为 7-52），显着高于 80 名年龄、性别和季节相匹配的慢性丙型肝炎患者（p = 1.16 × 10−8）。在多变量分析中，血清 25-羟基维生素 D3 缺乏的独立因素如下：女性（p = 2.03 × 10−4，优势比 = 2.290，95%置信区间 = 1.479–3.545）、年龄较大(p = 4.30 × 10−4，优势比 = 1.038，95%置信区间 = 1.017–1.060)，寒冷季节(p = 0.015，优势比 = 1.586，95%置信度间隔 = 1.095–2.297），血红蛋白水平较低（p = 0.037，比值比 = 1.165，95%置信区间 = 1.009–1.345）。相比之下，血清 25-羟基维生素 D3 充足的独立因素是男性（p = 0.001，比值比 = 3.400，95%置信区间 = 1.635–7.069）、温暖季节（p = 0.014，比值比 = 1.765， 95% 置信区间 = 1.117–2.789）和血清白蛋白（p = 0.016，OR = 2.247，95% CI = 1.163–4.342）。日本慢性丙型肝炎患者血清25-羟基维生素D3水平受性别、年龄、血红蛋白水平、白蛋白和测量季节的影响。
Serum 25-hydroxyvitamin D3 levels are generally lower in chronic hepatitis C patients than in healthy individuals. The purpose of this study is to clarify the factors which affect serum 25-hydroxyvitamin D3 levels using data obtained from Japanese chronic hepatitis C patients. The subjects were 619 chronic hepatitis C patients. Serum 25-hydroxyvitamin D3 levels were measured by using double-antibody radioimmunoassay between April 2009 and August 2014. Serum 25-hydroxyvitamin D3 levels of 20 ng/mL or less were classified as vitamin D deficiency, and those with serum 25-hydroxyvitamin D3 levels of 30 ng/mL or more as vitamin D sufficiency. The relationship between patient-related factors and serum 25-hydroxyvitamin D3 levels was analyzed. The cohort consisted of 305 females and 314 males, aged between 18 and 89 years (median, 63 years). The median serum 25-hydroxyvitamin D3 level was 21 ng/mL (range, 6–61 ng/mL). On the other hand, the median serum 25-hydroxyvitamin D3 level in the healthy subjects was 25 ng/mL (range, 7–52), being significantly higher than that those in 80 chronic hepatitis C patients matched for age, gender, and season (p = 1.16 × 10−8). In multivariate analysis, independent contributors to serum 25-hydroxyvitamin D3 deficiency were as follows: female gender (p = 2.03 × 10−4, odds ratio = 2.290, 95 % confidence interval = 1.479–3.545), older age (p = 4.30 × 10−4, odds ratio = 1.038, 95 % confidence interval = 1.017–1.060), cold season (p = 0.015, odds ratio = 1.586, 95 % confidence interval = 1.095–2.297), and low hemoglobin level (p = 0.037, odds ratio = 1.165, 95 % confidence interval = 1.009–1.345). By contrast, independent contributors to serum 25-hydroxyvitamin D3 sufficiency were male gender (p = 0.001, odds ratio = 3.400, 95 % confidence interval = 1.635–7.069), warm season (p = 0.014, odds ratio = 1.765, 95 % confidence interval = 1.117–2.789) and serum albumin (p = 0.016, OR = 2.247, 95 % CI = 1.163–4.342). Serum 25-hydroxyvitamin D3 levels in chronic hepatitis C Japanese patients were influenced by gender, age, hemoglobin level, albumin and the season of measurement.