Clinical trials: new opportunities.
Clinical trials: new opportunities.
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临床试验：新机遇。
DOI：
10.1093/gerona/gls126
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
vanDyck,ChristopherH
中科院分区：
文献类型：
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作者：
Chapman,SandraBond;Cotman,CarlW;Fillit,HowardM;Gallagher,Michela;vanDyck,ChristopherH
人类认知衰老因其对老年生活质量的至关重要性而长期被忽视和低估。本次会议的文章提出了基于流行病学发现、老年动物研究和体外研究的药物和干预措施来改善正常老年人认知功能的新方法。此外，由于衰老是阿尔茨海默病的主要危险因素，这些研究对于预防和治疗干预措施也具有重要意义。作为一个研究领域，关于认知衰老的原因和机制的新知识已经成熟，可以转化为人类研究，这些知识的应用引领了预防老年认知衰退和阿尔茨海默病的干预措施和治疗方法的开发。
Human cognitive aging has been too long neglected and underappreciated for its critical importance to quality of life in old age. The articles in this session present novel approaches to improving cognitive function in normal aging persons with drugs and interventions that are based on findings in epidemiology, studies in aged animals, and in vitro research. In addition, since aging is the primary risk factor for Alzheimer's disease, these studies also have implications as interventions for prevention and treatment. As a field of research, new knowledge regarding the causes and mechanisms of cognitive aging are ripe for translation into human studies, with the application of this knowledge leading the development of interventions and therapeutics for the prevention of cognitive decline in old age and Alzheimer's disease.