Inflammatory bowel disease in Iceland, 1990-1994:: a prospective, nationwide, epidemiological study
Inflammatory bowel disease in Iceland, 1990-1994:: a prospective, nationwide, epidemiological study
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DOI：
10.1097/00042737-200012010-00007
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发表时间：
2000-01-01
影响因子：
2.1
通讯作者：
Jóhannsson, JH
中科院分区：
文献类型：
--
作者：
Björnsson, S;Jóhannsson, JH
本研究的主要目的是前瞻性地调查1990-1994年间冰岛炎症性肠病(IBD)的发病率，以确定是否仍有持续上升的趋势。方法对冰岛所有三个病理科的所有炎症性结肠炎(UC)和克罗恩病(CD)新发病例的检索是基于对所有具有任何类型炎症的小肠和大肠组织标本的每月回顾。同时复习所有提示CD的小肠X线片。结果共确诊UC 215例，CD 72例，年平均发病率分别为UC 16.5/10万(95%可信区间14.4~18.9)和CD5.5/10万(95%CI 4.3~7.0)。年龄相关发病率以30~39岁组最高，为28.7/10万，10~19岁和20~29岁组最高，为8.5/10万。UC最常见的部位是直肠乙状结肠，CD最常见的部位仅限于结肠。结论这项前瞻性研究显示，冰岛UC和CD的发病率持续显著上升。之前发现的几个环境因素的总体变化不能得出任何关于它们在观察到的发病率增加中的作用的确切结论。可能还有其他一些原因(S)。(C)2000年Lippincott Williams&Wilkins。
Background Two separate nationwide, retrospective epidemiological studies of inflammatory bowel disease (IBD) in Iceland over a combined 40-year period, 1950-1989, have shown a continually rising incidence, The main objective of this study was to investigate the incidence of IBD prospectively for the 5-year period 1990-1994 to determine whether there still was an ongoing increase.Methods The retrieval of new cases of ulcerative colitis (UC) and Crohn's disease (CD) was based on a monthly review of all small and large intestinal tissue specimens with any type of inflammation submitted to all three departments of pathology in Iceland. All small intestinal X-ray records suggestive of CD were also reviewed. All possible new cases of IBD were then scrutinized by examination of the clinical records, using accepted criteria for confirmation or exclusion of IBD.Results A total of 215 cases of UC and 72 cases of CD were diagnosed, yielding a mean annual incidence for UC 16.5/100 000 (95% confidence interval (CI) 14.4-18.9), and for CD 5.5/100 000 (95% CI 4.3-7.0). The highest combined age related incidence for UC was 28.7/100 000 in the group aged 30-39 years, and for CD 8.5/100 000 in the groups aged 10-19 and 20-29 years. The most common extent in UC was proctosigmoid and the most frequent localization in CD was colonic only,Conclusions This prospective study demonstrates a continuing and statistically significant increase in the incidence of both UC and CD in Iceland. The general changes identified for a few previously suggested environmental factors do not allow any firm conclusions as to their role in the observed increase in incidence. It is possible that there are some other causative factor(s). (C) 2000 Lippincott Williams & Wilkins.