Relations Between Urinary Albumin Excretion and a Dietary Intake of Fruits in Patients With Type 2 Diabetes.
Relations Between Urinary Albumin Excretion and a Dietary Intake of Fruits in Patients With Type 2 Diabetes.
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2型糖尿病患者尿白蛋白排泄量与水果摄入量的关系
DOI：
10.14740/jocmr4440
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发表时间：
2021-03
期刊：
影响因子：
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通讯作者：
Yoshida H
中科院分区：
文献类型：
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作者：
Matsui S;Someya Y;Yoshida H
据报道，微量白蛋白尿和肾功能下降与心血管疾病（CVD）死亡率、肾脏事件和预后严重并发症相关。饮食因素和营养因素对2型糖尿病尿微量白蛋白的影响尚不清楚，因此我们对2型糖尿病患者饮食因素与尿白蛋白排泄的可能相关性进行了横断面研究。本研究共纳入42例2型糖尿病患者，将这些患者分为尿白蛋白与肌酐比值（ACR）小于30 mg/g Cr的无微量白蛋白尿组（n = 29）和尿微量白蛋白尿组（n = 13）， ACR为30 ~ 299 mg/g Cr。ACR水平通过尿样测定。检查时，测量并记录体重指数（BMI）、收缩压和舒张压。我们进行了空腹血和尿样取样，并进行了基于食物组的食物频率问卷调查，以检查过去1 - 2个月的饮食习惯。无微量白蛋白尿患者和微量白蛋白尿患者在性别、年龄、病程、BMI、血压、生化数据以及每日能量和常量营养素摄入量中位数方面无显著差异。在17个食物组中，微量白蛋白尿组的水果摄入量显著低于无微量白蛋白尿组（中位数为38 g/d vs. 120 g/d, P < 0.05），但其他食物组的摄入量在两组之间无显著差异。此外，我们研究了ACR与水果摄入量之间的部分相关模型，并根据年龄、性别、糖化血红蛋白和BMI进行了调整。偏相关不显著，但接近显著水平（偏相关系数：-0.270,P = 0.102）。这些结果表明，水果的摄入量可能与日本2型糖尿病患者的微量白蛋白尿呈负相关。有必要研究食用水果的确切种类和数量以解决微量白蛋白尿问题。
It was reported that microalbuminuria and a decline in renal function were associated with cardiovascular disease (CVD) mortality and renal events and prognostic serious complications. Dietary factors and nutrients affecting microalbuminuria in type 2 diabetes remain unclear, and accordingly we conducted a cross-sectional study on the possible relevance of dietary factors to urinary albumin excretion in patients with type 2 diabetes. Forty-two patients with type 2 diabetes participated in this study, and these subjects were categorized into patients without microalbuminuria group with urine albumin-to-creatinine ratio (ACR) of less than 30 mg/g Cr (n = 29) and a microalbuminuria group with ACR of 30 - 299 mg/g Cr (n = 13). ACR levels were measured using spot urine samples. At the time of examination, body mass index (BMI) and systolic and diastolic blood pressures were measured and recorded. We performed sampling fasting-blood and spot urine and conducted a food frequency questionnaire based on food groups to examine dietary habits for the past 1 - 2 months. There were no significant differences in sex, age, duration, BMI, blood pressures, biochemical data, and the median of daily intakes of energy and macronutrients between patients without microalbuminuria and microalbuminuria groups. In the intake of 17 food groups per day, fruits were significantly lower in the microalbuminuria group than in patients without microalbuminuria group (the median was 38 g vs. 120 g/day, P < 0.05), but intakes of other food groups were not significantly different between the two groups. Moreover, we examined a model of partial correlation between ACR to the intake of fruits, adjusted by age, sex, glycated hemoglobin and BMI. This partial correlation was insignificantly seen but close to a significant level (partial correlation coefficient: -0.270, P = 0.102). These results suggest that the intake of fruits may be inversely associated with microalbuminuria in Japanese type 2 diabetic patients. It would be necessary to investigate the exact types and amounts of fruits to be consumed to address microalbuminuria.