MALDI TIME-OF-FLIGHT MASS SPECTROMETRY OF SYNTHETIC POLYMERS
MALDI TIME-OF-FLIGHT MASS SPECTROMETRY OF SYNTHETIC POLYMERS
复制标题
DOI：
10.1002/(sici)1098-2787(1999)18:5
复制
发表时间：
1999
影响因子：
6.6
通讯作者：
M. Nielen
中科院分区：
文献类型：
--
作者：
M. Nielen
多年来，完整合成聚合物的质谱学仅限于场解吸质谱(FD-MS)。最近，电喷雾(ESI)和基质辅助激光解吸/电离(MALDI)等软电离技术以及飞行时间分析仪的复兴为聚合物的表征创造了新的机会。本文重点介绍了MALDI飞行时间质谱学的研究进展。选择合适的MALDI基质、阳离子盐和样品制备技术是获得可靠的质谱图和推断单体质量和端基等结构信息的关键成功因素。然而，即使在优化的条件下，多分散聚合物的分析中也可能出现质量歧视和特定低聚物的歧视。因此，诸如尺寸排除层析(SEC)/MALDI等联用技术已被开发出来。最近的文献中出现了许多不同的聚合物应用，但大多数研究都是针对均聚物的。仍然存在许多挑战，特别是在卤化聚合物、聚烯烃、共聚物、共混物和嵌段共聚物的排序方面。©1999 John Wiley&Sons，Inc.，质量规格修订版18：309-344,1999
Mass spectrometry of intact synthetic polymers has been limited to field desorption (FD) MS for many years. More recently, soft ionization techniques such as electrospray (ESI) and matrix-assisted laser desorption/ionization (MALDI) and the revival of time-of-flight analyzers created new opportunities for the characterization of polymers. In this review emphasis is put on MALDI time-of-flight mass spectrometry of polymers. The selection of an appropriate MALDI matrix, cationization salt and sample preparation techniques are critical success factors for obtaining a reliable mass spectrum and to infer structural information such as monomer mass(es) and end-groups. However even under optimized conditions mass discrimination in the analysis of polydisperse polymers and specific oligomer discrimination might occur. Hence hyphenated techniques such as size exclusion chromatography (SEC)/MALDI have been developed. Many different polymer applications appeared in recent literature, but most studies deal with homopolymers. Many challenges remain, particularly in the fields of halogenated polymers, polyolefines, copolymers, blends, and in the sequencing of block-copolymers. © 1999 John Wiley & Sons, Inc., Mass Spec Rev 18: 309–344, 1999