Synthesis of the Nonamannan Residue of a Glycoprotein with High Mannose Content
Synthesis of the Nonamannan Residue of a Glycoprotein with High Mannose Content
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DOI：
10.1002/anie.199601971
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发表时间：
1996-02
影响因子：
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通讯作者：
P. Grice;S. Ley;J. Pietruszka;H. Priepke
中科院分区：
文献类型：
--
作者：
P. Grice;S. Ley;J. Pietruszka;H. Priepke
刻意调节适当的糖基供体的反应性使得能够以简明的方式高效地制备农甘露聚糖1。1通过二糖接头结合，是人类免疫缺陷病毒(HIV)包膜糖蛋白gp120的主要成分。Gp120在HIV对靶细胞的附着和穿透以及抗病毒反应中起重要作用。
Deliberate tuning of the reactivity of the appropriate glycosyl donors enables nonamannan 1 to be prepared efficiently in a concise manner. Bound through a disaccharide linker, 1 is a major constituent of the envelope glycoprotein gp120 of the human‐immunodeficiency virus (HIV). Gp120 plays an important role in the attachment to and penetration of target cells by HIV and in the antiviral response.