Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims
Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims
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DOI：
10.1007/bf01294736
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发表时间：
1997-01-01
影响因子：
3.3
通讯作者：
Norlén, M
中科院分区：
文献类型：
--
作者：
Allard, P;Norlén, M
在抑郁状态下，关于血清素和去甲肾上腺素的理论一直占主导地位，但也有几条证据表明多巴胺系统也参与其中，特别是在自杀性抑郁症中。在这项死后研究中，研究了13名抑郁症自杀者和19名对照者尾状核中配体[H-3]WIN 35，428与多巴胺摄取位点的结合。自杀组与对照组之间的Bmax和Kd无差异。将自杀组再分为重性抑郁症、抗抑郁药物和自杀方法的亚组，没有产生任何差异。根据本研究，先前关于自杀性抑郁症患者CSF HVA降低和抑郁症患者纹状体多巴胺能生物化学和受体变化的研究结果似乎不能通过抑郁症自杀患者多巴胺摄取部位密度或亲和力的改变来反映。
In depressive states, theories concerning serotonin and norepinephrine have been dominating, but there are several lines of evidence indicating the involvement of the dopamine system as well, especially in suicidal depression. In this post-mortem study, the binding of the ligand [H-3]WIN 35,428 to dopamine uptake sites in the caudate nucleus was investigated in 13 depressed suicide victims and 19 controls. There were no differences in Bmax or Kd between the suicide group and controls. Subdividing the suicide group into subgroups regarding the presence of major depression, antidepressant medication and suicide method, respectively, did not yield any differences. Previous findings regarding reduced CSF HVA in suicidal depression and indications of striatal dopaminergic biochemical and receptor changes in depression seem, according to the present study, not to be reflected by alterations in density or affinity of dopamine uptake sites in depressed suicide victims.