Creatinine-or cystatin C-based equations to estimate glomerular filtration in the general population: impact on the epidemiology of chronic kidney disease.
Creatinine-or cystatin C-based equations to estimate glomerular filtration in the general population: impact on the epidemiology of chronic kidney disease.
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DOI：
10.1186/1471-2369-14-57
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发表时间：
2013-03-12
期刊：
影响因子：
2.3
通讯作者：
Bruyère O
中科院分区：
文献类型：
--
作者：
Delanaye P;Cavalier E;Moranne O;Lutteri L;Krzesinski JM;Bruyère O
慢性肾脏病（CKD）是公共卫生中的一个主要问题。其患病率是通过肾脏疾病改良饮食（MDRD）和慢性肾脏疾病流行病学协作组（CKD-EPI）研究中开发的肌酐方程估计肾小球滤过率（GFR）计算的。最近，CKD-EPI协会提出了基于半胱氨酸蛋白酶抑制剂C（CKD-EPI Cys）或半胱氨酸蛋白酶抑制剂和肌酐（CKD-EPI混合物）的新方程。本研究的目的是测量使用这四个方程的人群中3期CKD（定义为估计的GFR小于60 mL/min/1.73 m2）患病率的差异。CKD筛查在比利时列日省进行。50岁以上的人自愿接受检查。GFR由四个方程估计。3期CKD定义为GFR低于60 mL/min/1.73 m2。筛选的人群包括4189人（47%为男性，平均年龄63 ± 7岁）。他们的平均血清肌酐和血浆胱抑素C水平分别为0.88 ± 0.21 mg/dL和0.85 ± 0.17 mg/L。使用MDRD、CKD-EPI、CKD-EPI Cys和CKD-EPI混合方程，该人群中CKD的患病率分别为13%、9.8%、4.7%和5%。与新的基于半胱氨酸蛋白酶抑制剂C的方程相比，使用基于肌酐的方程（MDRD和CKD-EPI）的CKD患病率显著更高。CKD的患病率根据用于估计GFR的方法而变化很大。这种差异是重要的，必须通过额外的研究来证实和解释，特别是通过使用参考方法测量GFR的研究。B70720071509
Chronic kidney disease (CKD) is a major issue in public health. Its prevalence has been calculated using estimation of glomerular filtration rate (GFR) by the creatinine-based equations developed in the Modified Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) study. Recently, new equations based either on cystatin C (CKD-EPI Cys) or both cystatin and creatinine (CKD-EPI mix) have been proposed by the CKD-EPI consortium. The aim of this study was to measure the difference in the prevalence of stage 3 CKD, defined as an estimated GFR less than 60 mL/min/1.73 m2, in a population using these four equations. CKD screening was performed in the Province of Liège, Belgium. On a voluntary basis, people aged over 50 years have been screened. GFR was estimated by the four equations. Stage 3 CKD was defined as a GFR less than 60 mL/min/1.73 m2. The population screened consisted of 4189 people (47% were men, mean age 63 ± 7y). Their mean serum creatinine and plasma cystatin C levels were 0.88 ± 0.21 mg/dL and 0.85 ± 0.17 mg/L, respectively. The prevalence of CKD in this population using the MDRD, the CKD-EPI, the CKD-EPI Cys and the CKD-EPI mix equations was 13%, 9.8%, 4.7% and 5%, respectively. The prevalence of CKD was significantly higher with the creatinine-based (MDRD and the CKD-EPI) equations compared to the new cystatin C-based equations. Prevalence of CKD varies strongly depending on the method used to estimate GFR. Such discrepancies are of importance and must be confirmed and explained by additional studies, notably by studies using GFR measured with a reference method. B70720071509
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影响因子：
2.3
作者：
Delanaye P;Cavalier E;Mariat C;Maillard N;Krzesinski JM
通讯作者：
Krzesinski JM
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
DOI：
10.1097/qai.0b013e31826a6c4f
发表时间：
2012-11-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Inker LA;Wyatt C;Creamer R;Hellinger J;Hotta M;Leppo M;Levey AS;Okparavero A;Graham H;Savage K;Schmid CH;Tighiouart H;Wallach F;Krishnasami Z
通讯作者：
Krishnasami Z
影响因子：
13.6
作者：
Hallan, Stein I.;Coresh, Josef;Holmen, Jostein
通讯作者：
Holmen, Jostein
影响因子：
120.7
作者：
Hallan, Stein I.;Matsushita, Kunihiro;Sang, Yingying;Mahmoodi, Bakhtawar K.;Black, Corri;Ishani, Areef;Kleefstra, Nanne;Naimark, David;Roderick, Paul;Tonelli, Marcello;Wetzels, Jack F. M.;Astor, Brad C.;Gansevoort, Ron T.;Levin, Adeera;Wen, Chi-Pang;Coresh, Josef
通讯作者：
Coresh, Josef