Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity
Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity
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DOI：
10.1016/s0092-8674(00)80658-3
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发表时间：
1999-02-19
期刊：
影响因子：
64.5
通讯作者：
Zuker, CS
中科院分区：
文献类型：
--
作者：
Hoon, MA;Adler, E;Zuker, CS
在动物王国里，味觉是一种主要的感官输入形式。在哺乳动物中，味觉感知始于舌头和腭上皮受体细胞的顶端表面未知的膜受体对味觉分子的识别。我们报道了在味觉受体细胞和味蕾的不同亚群中表达的两个新的七跨膜结构域蛋白的克隆和表征。这些蛋白特异定位于味觉孔，是一组新的G蛋白偶联受体的成员，与假定的哺乳动物信息素受体有远亲关系。我们认为这些基因编码味觉感受器。
Taste represents a major form of sensory input in the animal kingdom. In mammals, taste perception begins with the recognition of tastant molecules by unknown membrane receptors localized on the apical surface of receptor cells of the tongue and palate epithelium. We report the cloning and characterization of two novel seven-transmembrane domain proteins expressed in topographically distinct subpopulations of taste receptor cells and taste buds. These proteins are specifically localized to the taste pore and are members of a new group of G protein-coupled receptors distantly related to putative mammalian pheromone receptors. We propose that these genes encode taste receptors.