Experimental studies on early lens changes after roentgen irradiation. II. Exchange and penetration of radioactive indicators (Na24, K42, I131, P32) in normal and irradiated lenses of rabbits.
Experimental studies on early lens changes after roentgen irradiation. II. Exchange and penetration of radioactive indicators (Na24, K42, I131, P32) in normal and irradiated lenses of rabbits.
复制标题
伦琴照射后早期晶状体变化的实验研究。
DOI：
10.1001/archopht.1951.01700010441010
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发表时间：
1951
期刊：
影响因子：
--
通讯作者：
B. D. Locke
中科院分区：
文献类型：
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作者：
L. V. Sallman;B. D. Locke
在这一部分的研究中，放射性示踪剂被用来研究x射线照射对晶状体和血水屏障通透性的影响，只要它能从这个实验顺序中推断出来。许多研究者认为，相界通透性的改变可能在x射线白内障的发病过程中起重要作用。此外，人们普遍认为，电离辐射的生物作用部分或全部基于细胞膜选择性通透性的改变。这些变化可以影响物质进入细胞的速度，以及它们的消除速度，从而可能改变代谢和合成过程。据我们所知，在进行本研究时，没有对眼睛进行过可以支持或反驳这一理论的广泛调查。两种实验技术，各部分补充
RADIOACTIVE tracers were employed in this part of the study to investigate the effect of roentgen irradiation on the permeability of the lens and of the blood-aqueous barrier as far as it could be deduced from this order of experiment. According to many workers, changes in the permeability of phase boundaries may play an important part in the pathogenesis of roentgen ray cataract. It is widely held, moreover, that the biologic actions of ionizing radiations are based partly or entirely on alterations in the selective permeability of the cell membrane. These changes can influence the rate of entrance of substances into the cells, and of their elimination, and thus may modify metabolic and synthetic processes. To the best of our knowledge, no extensive investigations on the eye which could lend support to this theory or disprove it had been carried out at the time the present study was undertaken. Two experimental technics, each in part supplementary to the