A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium
A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium
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DOI：
10.1359/jbmr.040114
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发表时间：
2004-05-01
影响因子：
6.2
通讯作者：
Quarles, LD
中科院分区：
文献类型：
--
作者：
Pi, M;Quarles, LD
确定锶在成骨细胞中的分子靶点对于理解这种阳离子对骨的合成代谢作用非常重要。目前的研究表明，G蛋白介导的反应，锶持续在成骨细胞缺乏CASR，这表明一种新的阳离子敏感受体在介导骨反应锶的主导作用。
Defining the molecular target for strontium in osteoblasts is important for understanding the anabolic effects of this cation on bone. The current studies demonstrate that a G-protein-mediated response to strontium persists in osteoblasts that lack CASR, suggesting a predominant role for a novel cation-sensing receptor in mediating the osseous response to strontium.