In vitro sensitivity of median preoptic neurons to angiotensin II, osmotic pressure, and temperature.
In vitro sensitivity of median preoptic neurons to angiotensin II, osmotic pressure, and temperature.
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中位视前神经元对血管紧张素 II、渗透压和温度的体外敏感性。
DOI：
10.1152/ajpregu.1993.264.6.r1200
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Johnson,AK
中科院分区：
文献类型：
--
作者：
Travis,KA;Johnson,AK
体内实验表明参与体液平衡和体温调节的机制之间存在相互作用。血浆渗透压的增加会引发饮酒并增加出汗的热设定点。正中视前核（MnPO）与对液体平衡和心血管调节很重要的大脑区域以及视前下丘脑前部温度调节区域具有解剖学联系。本实验采用体外单单位记录来确定 MnPO 神经元对血管紧张素 II (ANG II)、渗透压变化和温度变化的敏感性。五分之一（55 个中的 11 个）的 MnPO 神经元在 ANG II 治疗期间对放电速率的变化做出反应，四分之一（75 个中的 19 个）对灌注液渗透压的变化做出反应，并且渗透压和 ANG II 对 25% 的测试神经元的热敏感性有显着影响。
In vivo experiments suggest an interaction of the mechanisms involved in the regulation of body fluid balance and body temperature. Increases in plasma osmolality initiate drinking and increase the thermal set point for sweating. The median preoptic nucleus (MnPO) has anatomical connections with brain areas important in fluid balance and cardiovascular regulation and, with the preoptic-anterior hypothalamus, a thermoregulatory region. The present experiments employed in vitro single-unit recordings to determine the sensitivity of MnPO neurons to angiotensin II (ANG II), changes in osmotic pressure, and changes in temperature. One-fifth (11 of 55) of the MnPO neurons responded with changes in firing rate during the ANG II treatment, one-fourth (19 of 75) responded to changes in perfusate osmolality, and there was a significant effect of osmolality and ANG II on the thermosensitivity of 25% of the neurons tested.