The incidence and distribution of cupular deposits in the pediatric vestibular labyrinth
The incidence and distribution of cupular deposits in the pediatric vestibular labyrinth
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DOI：
10.1097/00005537-200201000-00026
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发表时间：
2002-01-01
期刊：
影响因子：
2.6
通讯作者：
Karmody, CS
中科院分区：
文献类型：
--
作者：
Bachor, E;Wright, CG;Karmody, CS
目的：在成人颞骨中发现了半规管顶端的嗜碱性物质沉积，这种沉积与良性阵发性位置性眩晕(BPPV)的临床现象有关。虽然相对罕见，但BPPV已被报道发生在儿童中。这项研究的目的是评估儿科材料中杯状沉积物的发生情况。研究设计：基础科学，双中心组织病理学颞骨研究。方法：对121例新生儿至10岁儿童的186块颞骨进行了检查。平均年龄14.7个月。所有的颞骨都是在尸检时获取的，用火棉胶包埋，切片进行光镜研究。确定了半圆形导管的顶盖，并根据它们在顶盖上的大小和位置对发现的任何沉积物进行了分级。结果：共鉴定出276个杯状物，其中35个(12.7%)发现了嗜碱性沉积物。在许多情况下，沉积物中含有可辨认的耳锥晶体。大多数沉积物都很小，它们几乎平均分布在三个半圆形管道之间。然而，外侧和后顶盖比上顶盖受累更多。我们的数据显示，与先前研究报告的成人相比，儿童迷路中发现杯状沉积物的频率较低。结论：儿童较成人发生率低，提示沉积可能是前庭迷路老化的一种现象。
Objectives: Deposits of basophilic material on the cupulae of the semicircular ducts have been described in adult human temporal bones, and such deposits have been implicated in the clinical phenomenon of benign paroxysmal positional vertigo (BPPV). Although relatively rare, BPPV has been reported to occur in children. The goal of this study was to evaluate the occurrence of cupular deposits in pediatric material. Study Design: Basic science, two-center histopathologic temporal bone study. Methods: We examined 186 temporal bones from 121 individuals between the ages of newborn and 10 years. The average age was 14.7 months. All temporal bones were acquired at autopsy, embedded in celloidin, and sectioned for light microscopic study. The cupulae of the semicircular ducts were identified and any deposits found were graded according to their size and position on the cupula. Results: A total of 276 cupulae were identified, and in 35 (12.7%) of these a basophilic deposit was found. In many cases the deposits contained recognizable otoconial crystals. Most deposits were small and they were almost equally distributed between the three semicircular ducts. However, the lateral and posterior cupulae were somewhat more involved than the superior cupula. Our data showed that cupular deposits are less frequently found in the pediatric labyrinth, compared with adults as reported in previous studies. Conclusions: The lower occurrence in children versus adults suggests that the deposits may be a phenomenon of the aging vestibular labyrinth.