Toxic effects of TiO(2) NPs in the blood-milk barrier of the maternal dams and growth of offspring.
Toxic effects of TiO(2) NPs in the blood-milk barrier of the maternal dams and growth of offspring.
复制标题
TiO(2) NPs 对母鼠血乳屏障和后代生长的毒性作用。
DOI：
10.1016/j.ecoenv.2020.111762
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发表时间：
2021
影响因子：
6.8
通讯作者：
Xu Hengyi
中科院分区：
文献类型：
--
作者：
Yao Liyang;Chen Ling;Chen Bolu;Tang Yizhou;Zhao Yu;Liu Shanji;Xu Hengyi
二氧化钛纳米颗粒（TiO2NP）是日常消费品中最常用的纳米材料之一，其广泛应用引起了人们对随之而来的对人类健康的有害影响的担忧，特别是对弱势群体（例如哺乳期女性）的影响仍然难以捉摸。因此，本研究旨在探讨TiO2NPs对母鼠和子代哺乳期的有害影响和毒性机制。水坝被随机分为三组。出生后第 1-20 天分别口服水（对照组；第 I 组）和 TiO2NP（100 mg/kg；第 II 组）。结果表明，TiO2NPs 可能对母鼠产生毒性，如乳腺组织的病理损伤。 TiO2NPs的过度积累会引起乳腺氧化应激，导致血乳屏障功能失调；此外，TiO2NPs还可以通过母乳喂养传递给后代，导致婴儿发育异常。我们进一步探究了可能的潜在分子机制；为此，我们口服 TiO2NP 和维生素 E（100 毫克/千克；第 III 组）。结果表明，TiO2NPs 引起的毒性得到了缓解。总的来说，这项研究提出了口服 TiO2NPs 通过在母体中产生活性氧 (ROS) 以及对后代的发育问题，对乳腺组织和血乳屏障产生有害的病理影响。然而，施用 VE 可以减轻 TiO2NPs 引起的毒性作用。
Titanium dioxide nanoparticles (TiO2NPs) are amongst the most frequently used nanomaterial in everyday consumer products, and their widespread applications have raised concerns of the consequent deleterious effects on human health, particularly to vulnerable populations, such as lactating females remains elusive. Therefore, this study was initiated to investigate the detrimental effects and toxic mechanisms induced by TiO2NPs in maternal dams and offspring during the lactation period. Dams were randomly divided into three groups. The water (Control; Group I) and TiO2NPs (100 mg/kg; Group II) were orally administered from postnatal day 1–20, respectively. The results indicated that TiO2NPs could cause toxicity in the dams, such as pathological damages to mammary gland tissues. The excessive accumulation of TiO2NPs could induce oxidative stress in the mammary gland, leading to the dysfunctional blood-milk barrier; besides, TiO2NPs could also be transferred to offspring via breastfeeding, causing abnormal development of infant. We further accessed the possible underlying molecular mechanism; for this, we orally administered TiO2NPs with vitamin E (100 mg/kg; Group III). The results revealed that toxicity induced by TiO2NPs was rescued. Collectively, this study presented the deleterious pathological effects of oral exposure to TiO2NPs in the mammary gland tissues and blood-milk barrier via the production of reactive oxygen species (ROS) in dams and developmental concerns in offspring. However, the administration of VE could mitigate the toxic effects induced by the TiO2NPs.