Growth hormone catecholamines in affective disease.
Growth hormone catecholamines in affective disease.
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生长激素儿茶酚胺在情感疾病中的作用。
DOI：
10.1176/ajp.132.11.1149
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
F. DeLeon
中科院分区：
文献类型：
--
作者：
D. Garver;G. Pandey;H. Dekirmenjian;F. DeLeon
作者研究了胰岛素诱导的低血糖（HI）后生长激素（GH）的释放与尿MHPG（中枢去甲肾上腺素的主要代谢产物）的关系。单极抑郁症患者和躁狂患者HI后尿MHPG水平与GH峰值呈显著的线性相关；然而，与单极抑郁症患者相比，躁狂患者的生长激素峰值在生长激素轴上向下移动。作者认为，这种生长激素反应的变化可能是其他神经递质系统异常的结果，这些神经递质系统也有助于生长激素的释放。
The authors studied growth hormone (GH) release after insulin-induced hypoglycemia (HI) in relation to urinary MHPG, the major metabolite of central norepinephrine. There was a significant linear correlation of urinary MHPG levels and GH peaks after HI in unipolar depressed patients and in manic patients; however, GH peaks in manic patients shifted downward on the GH axis in comparison to the unipolar depressive patients. The authors suggest that such shifts in the GH response may occur as a result of abnormalities of other neurotransmitter systems also known to facilitate GH release.