A registration strategy to characterize DTI-observed changes in skeletal muscle architecture due to passive shortening.
A registration strategy to characterize DTI-observed changes in skeletal muscle architecture due to passive shortening.
复制标题
一种配准策略，用于表征由于被动缩短而导致的 DTI 观察到的骨骼肌结构变化。
DOI：
10.1101/2024.04.11.589123
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Damon,BruceM
中科院分区：
文献类型：
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作者：
Hooijmans,MelissaT;Lockard,CarlyA;Zhou,Xingyu;Coolbaugh,Crystal;PinedaGuzman,Roberto;Kersh,MarianaE;Damon,BruceM
骨骼肌结构是肌肉功能的关键决定因素。束长度、羽状角度和曲率等建筑特性可以使用扩散张量成像 (DTI) 进行表征，但在收缩过程中获取这些数据目前还不可行。然而，基于图像配准的策略可能能够将静止时观察到的肌肉结构特性转换为其收缩状态。作为实现这一长期目标的第一步，本研究的目的是确定是否可以使用图像配准策略将在被动旋转后在伸展关节位置观察到的全肌肉平均结构特性转换为弯曲位置的结构特性。使用 3T MR 系统在 + 20° 和 -10° 踝关节位置对七名健康参与者的小腿进行 DTI 和高分辨率脂肪/水扫描。来自两个位置的扩散和解剖图像用于从种子点沿着纤维插入腱膜的网格表示传播 DTI 纤维束。记录-10°和+ 20°解剖图像，并使用位移场将网格和纤维束从+ 20°位置变换到-10°位置。学生的配对测试用于比较原始纤维束和转换后纤维束之间的平均结构参数。全肌肉平均纤维束长度、羽状角度、曲率和生理横截面积估计值没有显着差异。跖屈时的 DTI 纤维束可以转变为背屈位置，而不会显着影响纤维束的平均结构特征。将来，可以使用类似的方法来评估收缩状态下的肌肉结构。
Skeletal muscle architecture is a key determinant of muscle function. Architectural properties such as fascicle length, pennation angle, and curvature can be characterized using Diffusion Tensor Imaging (DTI), but acquiring these data during a contraction is not currently feasible. However, an image registration-based strategy may be able to convert muscle architectural properties observed at rest to their contracted state. As an initial step toward this long-term objective, the aim of this study was to determine if an image registration strategy could be used to convert the whole-muscle average architectural properties observed in the extended joint position to those of a flexed position, following passive rotation. DTI and high-resolution fat/water scans were acquired in the lower leg of seven healthy participants on a 3T MR system in + 20° and −10° ankle positions. The diffusion and anatomical images from the two positions were used to propagate DTI fiber-tracts from seed points along a mesh representation of the aponeurosis of fiber insertion. The −10° and + 20° anatomical images were registered and the displacement fields were used to transform the mesh and fiber-tracts from the + 20° to the −10° position. Student’s pairedt-tests were used to compare the mean architectural parameters between the original and transformed fiber-tracts. The whole-muscle average fiber-tract length, pennation angle, curvature, and physiological cross-sectional areas estimates did not differ significantly. DTI fiber-tracts in plantarflexion can be transformed to dorsiflexion position without significantly affecting the average architectural characteristics of the fiber-tracts. In the future, a similar approach could be used to evaluate muscle architecture in a contracted state.