Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway
Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway
复制标题
DOI：
10.1016/j.intimp.2015.07.040
复制
发表时间：
2015-09-01
影响因子：
5.6
通讯作者：
Cao, Rongfeng
中科院分区：
文献类型：
--
作者：
Li, Weishi;Fu, Kaiqiang;Cao, Rongfeng
乳铁蛋白（LF）是在牛奶中发现的最丰富的蛋白质之一，据报道它具有抗炎特性。然而，LF对脂多糖（LPS）诱导的腹膜炎的抗炎作用和潜在的分子机制仍有待阐明。本研究探讨了LF对LPS诱导的小鼠腹膜炎的影响。采用LPS灌胃法建立小鼠腹膜炎模型。在LPS诱导前1 h和诱导后12 h腹腔注射LF。结果表明，LF能显著减轻子宫组织病理学改变，降低髓过氧化物酶（MPO）活性和一氧化氮（NO）水平，抑制NF-κ B B活化、肿瘤坏死因子-α（TNF-α）和白细胞介素-1 β（IL-1 β）表达，并呈剂量依赖性。结果表明，LF对LPS诱导的小鼠子宫内膜炎具有抗炎作用。因此，LF可能是一种潜在的治疗前列腺炎的药物。(C)2015 Elsevier B. V.版权所有。
Lactoferrin (LF) is one of the most abundant proteins found in milk, and it has been reported to have anti-inflammatory properties. However, the anti-inflammatory effects of LF on lipopolysaccharide (LPS)-induced endometritis and the underlying molecular mechanisms remain to be elucidated. In this study, we evaluated the effects of LF on LPS-induced endometritis in mice. The endometritis model was established by the perfusion of mice with LPS. LF was administered by intraperitoneal injection 1 h before and 12 h after LPS induction. Our results demonstrated that LF significantly attenuated the histopathological changes in the uterus, reduced the activity of myeloperoxidase (MPO) and the levels of nitric oxide (NO), and inhibited the activation of NF-kappa B and the expression of tumor necrosis factor-alpha (TNF-alpha) and interleuldn-1 beta (IL-1 beta) in a dose-dependent manner. The results suggest that LF has an anti-inflammatory effect on LPS-induced endometritis in mice. Therefore, LF may be a potential therapeutic agent for the treatment of endometritis. (C) 2015 Elsevier B.V. All rights reserved.