Characteristics of bone metabolism in postmenopausal women with newly diagnosed type 2 diabetes mellitus
Characteristics of bone metabolism in postmenopausal women with newly diagnosed type 2 diabetes mellitus
复制标题
绝经后初诊2型糖尿病女性骨代谢特征
DOI：
10.1111/cen.14501
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发表时间：
2021-06-15
影响因子：
3.2
通讯作者：
Song, Lige
中科院分区：
文献类型：
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作者：
Li, Huijuan;Wen, Yuhua;Song, Lige
目的2型糖尿病（T2DM）的骨代谢特点目前仍存在争议。本研究的目的是认识新诊断的T2DM患者的骨转换功能从来没有被治疗过的抗糖尿病药物，并进一步探讨可能的因素，他们受损的骨turnovers.Materials和方法88例新诊断的T2DM患者和152名非糖尿病对照组的分析样本进行了研究。所有参与者均为绝经后妇女。记录人口统计学变量和临床病史。检测血脂、糖代谢、骨转换指标及其相关激素、血清钙磷水平。双能X线骨密度仪检测骨密度。结果与对照组相比，T2DM患者骨碱性磷酸酶（BALP）水平升高，I型前胶原完整N端（P1NP）、骨钙素（OC）和甲状旁腺激素（PTH）水平降低。多元线性回归分析显示，T2DM患者HbA1c与P1NP、OC呈负相关。非糖尿病患者HbA1c与BALP、OC呈负相关。结论初诊T2DM患者存在成骨细胞成熟和骨形成障碍，其主要原因可能是高血糖。
Objective The characteristics of bone metabolism in T2DM are still controversial. This study aims to recognize bone turnover features in patients with newly diagnosed T2DM who have never been treated with anti-diabetic drugs and further explore the possible factors contributing to their impaired bone turnover.Materials and Methods An analytic sample of 88 patients with newly diagnosed T2DM and 152 non-diabetic control individuals were studied. All the participants were postmenopausal women. Demographics variables and clinical history were recorded. We measured lipid profile, glucose metabolism, bone turnover markers indices as well as their related hormones, serum calcium and phosphorus. Bone mineral density was detected by dual-energy X-ray absorptiometry. We compared the differences in bone turnover markers and their regulating hormones between two groups and further analysed the factors related to bone turnover in T2DM.Results Compared with the control group, patients with T2DM had a higher level of bone alkaline phosphatase (BALP), lower levels of procollagen type I intact N-terminal (P1NP), osteocalcin (OC) and parathyroid hormone (PTH). Multiple linear regression analysis showed that in patients with T2DM, HbA1c was negatively correlated with P1NP and OC. For patients without diabetes, HbA1c was negatively related to BALP and OC.Conclusions Patients with newly diagnosed T2DM may have impaired osteoblastic maturation and bone formation, which may be mainly attributed to hyperglycaemia.