Probiotic Administration in Infants With Gastroschisis: A Pilot Randomized Placebo-Controlled Trial.
Probiotic Administration in Infants With Gastroschisis: A Pilot Randomized Placebo-Controlled Trial.
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DOI：
10.1097/mpg.0000000000001031
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发表时间：
2016-06
影响因子：
2.9
通讯作者：
Underwood MA
中科院分区：
文献类型：
--
作者：
Powell WT;Borghese RA;Kalanetra KM;Mirmiran M;Mills DA;Underwood MA
婴儿腹裂往往需要长期的胃吸痰和住院治疗。这些干预措施对肠道微生物群的影响以及改变微生物群落的尝试尚未得到研究。我们试图确定肠微生物群如何受到当前腹裂治疗的影响，以及用益生菌改变肠微生物群是否会影响住院时间。我们对24名腹裂婴儿进行了一项随机、安慰剂对照的试验性研究，研究中使用了益生菌长双歧杆菌亚种。主要结果是粪便微生物群的变化，次要结果是住院时间。益生菌或安慰剂的给药耐受性良好，即使在胃吸痰期间。总体微生物群落在组间无显著差异，但按家族对最终标本的分析表明，益生菌组中双歧杆菌科较高，梭菌科较低，肠杆菌科、肠球菌科、葡萄球菌科和链球菌科的趋势较低。临床结果，包括住院时间在两组之间没有差异。在这项初步研究中，腹裂婴儿存在显著的生态失调，通过给予长双歧杆菌亚种可部分减弱。
Infants with gastroschisis often require long periods of gastric suctioning and hospitalization. The impact of these interventions on the intestinal microbiota and attempts to alter the microbial community have not been studied. We sought to determine how the intestinal microbiota is influenced by current treatment of gastroschisis and whether alteration of the intestinal microbiota with a probiotic microbe will influence length of hospitalization. We performed a randomized, placebo-controlled pilot study of administration of probiotic Bifidobacterium longum subsp infantis in 24 infants with gastroschisis. The primary outcome was changes in the fecal microbiota and the secondary outcome was length of hospital stay. Administration of the probiotic or placebo was well tolerated, even during the period of gastric suctioning. The overall microbial communities were not significantly different between groups, though analysis of the final specimens by family demonstrated higher Bifidobacteriaceae, lower Clostridiaceae, and trends toward lower Enterobacteriaceae, Enterococcaceae, Staphylococcaceae, and Streptococcaceae in the probiotic group. Clinical outcomes, including length of hospital stay did not differ between groups. In this pilot study there was significant dysbiosis in infants with gastroschisis that was partially attenuated by administration of Bifidobacterium longum subsp infantis.