Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: Biodegradation
Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: Biodegradation
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DOI：
10.1163/156856201744425
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发表时间：
2001-01-01
影响因子：
3.6
通讯作者：
Wang, N
中科院分区：
文献类型：
--
作者：
Wu, XS;Wang, N
研究了一系列不同乳酸/乙醇酸摩尔比、不同相对分子质量的乳酸/乙醇酸聚合物(PLGA)的生物降解行为，特别是影响生物降解率的因素。PLGA的生物降解性受多种因素的影响，包括聚合物组成。分子量和孵化介质的性质。乳酸含量较高的PLGA的生物降解率低于乳酸含量较低的PLGA。具有较高相对分子质量的PLGA比具有较低相对分子质量的PLGA降解更快，即对于较高相对分子质量的PLGA，其相对分子质量下降得更快。水解/培养介质的性质或性质可能会对PLGA的生物降解产生影响。与在酸性介质中的样品相比，碱性介质可能会减缓PLGA的生物降解。培养液的pH下降速度可分为三个不同的阶段，无缓冲培养液的pH曲线呈倒S式。
A series of previously-synthesized lactic/glycolic acid polymers (PLGA) with various molar ratios of lactic to glycolic acid and various molecular weights were further studied with regard to their biodegradation behavior, and in particular, the factors affecting the biodegradation rate. The biodegradation of PLGA is affected by many factors including polymer composition. molecular weight, and nature of the incubating media. The biodegradation rate of PLGA containing higher content of lactic acid moiety is lower than those containing a lower content of lactic acid moiety. PLGAs with a higher molecular weight, degrade faster than those with a lower molecular weight, i.e. the molecular weight decreases more rapidly for higher molecular weight PLGAs than their lower molecular weight counterparts. Nature or properties of the hydrolysis/incubating media may have an effect on the biodegradation of PLGAs. A basic medium may slow down the biodegradation of PLGA in comparison with samples in an acidic medium. The rate of pH reduction for the incubating medium can be divided into three deferent phases, giving an inverted S-type pH profile for the non-buffered incubating media.